| Wei Daoyan,Jing Aoxing,Wang Siying.Augmentation of antitumor effects in mice by low dose X-ray whole body irradiation :in toto and in vitro studies[J].Chinese Journal of Radiological Medicine and Protection,1996,16(3):151-153 |
| Augmentation of antitumor effects in mice by low dose X-ray whole body irradiation :in toto and in vitro studies |
| Received:March 21, 1995 Revised:July 14, 1995 |
| DOI： |
| KeyWords:Low dose radiation B16 melanoma Lewis lung carcinoma(LLC) tumor metastases |
| FundProject:国家自然科学基金 |
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| Abstract:: |
| By using the models of hematogenous and spontaneous tumor metastases, the influence of 75mGy X-ray whole-body irradiation on antitumor ability of mice was investigated in toto and in vitro.The results were as follows:(1)As compared with unirradiated control mice, the number of hematogenous pulmonary metastatic colonies of B16 melanoma decreased obviously(P<0.01) in 75mGy X-ray irradiated mice;the splenocytes of the irradiated mice adoptively transferred to syngeneic mice significantly inhibited Lewis lung carcinoma(LLC) growth and spontaneous pulmonary metastasis(P<0.05～0.01).(2) Comparing with those of unirradiated control mice, the in vitro response of NK cytotoxity of the splenocytesfrom irradiated mice to ConA and IL-2 increased greatly, the macrophage function was higher and the retention of 125 IUdR-labeled B16 melanoma cells in lungs was lower for the irradiated mice tested in vivo(P<0.01).Our results indicate that low dose radiation can augment murine antitumor ability;the enhancement of immunofunctions may be one of the main reasons for its antitumor effects. |
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