Jiang Benrong.Lymphocyte micronucleus assay can be used as a biological dosimeter in radiation accident[J].Chinese Journal of Radiological Medicine and Protection,1996,16(2):105-108 |
Lymphocyte micronucleus assay can be used as a biological dosimeter in radiation accident |
Received:December 05, 1994 Revised:April 27, 1995 |
DOI: |
KeyWords:Micronuclei biological dosimeter calibration curve cytokinesisblock micronucleus method radiation accident |
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Abstract:: |
We utilized micronucleus (MN) dose-effect calibration curves obtained by cytokinesis-block (CB) method and conventional method to estimate the biological doses to three irradiated persons in a60 Co source accident in Wuhan and one case of nonHodgkin's lymphoma total bodily irradiated with60Co source.The results showed that(1) the doses estimated by micronucleus assay were consistent with those by physical dosimetry and chromosome aberration analysis;(2) the doses estimated 31 days post irradiation were still consistent with those originally estimated to the three accidental cases,although the former were a little lower than the latter.We consider that all of these MNC or MN calibration curves obtained by either CB MN method or conventional MN method could be used as biological dosimeters to estimate the exposure dose in radiation accident. |
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