| Wang Baoqin,Xiong Jingfeng,Wang Jue,et al.Effects of fission-neutron irradiation on proliferation of lymphocytes in murine spleen[J].Chinese Journal of Radiological Medicine and Protection,1996,16(2):100-104 |
| Effects of fission-neutron irradiation on proliferation of lymphocytes in murine spleen |
| Received:January 13, 1995 Revised:April 13, 1995 |
| DOI： |
| KeyWords:Fission neutrons spleen lymphocytes proliferation mice |
| FundProject: |
| Author Name | Affiliation | | Wang Baoqin | Institute of Radiation Medicine, Beijing, 100850 | | Xiong Jingfeng | Institute of Radiation Medicine, Beijing, 100850 | | Wang Jue | Institute of Radiation Medicine, Beijing, 100850 | | 谭洪玲 | Institute of Radiation Medicine, Beijing, 100850 | | 涂开成 | Institute of Radiation Medicine, Beijing, 100850 |
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| Abstract:: |
| in this paper the proliferative function of splenic lymphocytes in mice irradiated with graded doses of fission neutron was investigated 24h after radiation, using the method of 3M-TdR incorporation after mitogen stimulation.At the same tune, the characteristics of injury and repair of proliferative function after 2. 3Gy neutron irradiation were compared with those after equivalent lethal dose of 60Co γ-rays.The changes in the number of murine splenic lymphocytes indicate that there are two components in it: the radiosensitive and radioresistant to neutron radiation and γ-radiation, the radiosensitivity to neutrons is higher than that toγ-rays in the same component. D0 values of the radiosensitive cells to neutrons and toγ-rays are 0.40 Gy and 0.96 Gy, respectively.Therefore, RBE= 2.40. After radiation the proliferative response curves of splenic lymphocytes stimulated by ConA or by LPS show that both of T and B lymphocytes consist of two different radiosensitive components. D37 value of T cells which possess high sensitivity to neutron irradiation is about 0. 82 Gy, that of B cells about 1.05 Gy. D37 values of T cells and B cells toγ-rays are 0.75 Gy and 2. 38 Gy, respectively. Hence, RBE values are 0. 91 and 2. 27, correspondingly. After irradiation of 2.3 Gy fission-neutrons or 4.5 Gy γ-rays,the tendency of damage and recovery of the transformation function of murine splenic T lymphocytes stimulated by ConA is about the same, and that of B lymphocytes stimulated by LPS has the same pattern. |
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