| Zhu Maoxiang,Gong Yifen,Ge Guixiu.Effect of free radicals released from pulmonary alveolar phagocytes on development of radiation pneumonia in rats[J].Chinese Journal of Radiological Medicine and Protection,1996,16(2):96-99 |
| Effect of free radicals released from pulmonary alveolar phagocytes on development of radiation pneumonia in rats |
| Received:September 05, 1994 Revised:March 13, 1995 |
| DOI： |
| KeyWords:Pulmonary alveoli phagocytes free radicals hydoxylproline chemiluminescence selenium. |
| FundProject:解放军总后勤部八五攻关课题 |
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| Abstract:: |
| Measuring the hydroxylproline(HyP) content in rat lungs and the chemiluminescence(CL) of bronchus alveolar lavage fluid cell (BALFC) at 0.5,1 and 2 months after irradiation with 60Co γ-rays respectively, we found that the amount of BALFC and its CL stimulated by zymosan and the pulmonary HyP content were apparently increased after irradiation,and these alternations took a favourable turn when selenium was supplemented to irradiated rats,suggesting that selenium protected the rats from radiation injury of lung. In addition,we found that there were certain interrelations between the multiplication of pulmonary fibrocytes and the free radicals released from accumulated BALFC in pulmonary alveoli,indicating that the free radicals produced from alveolar phagocytes may be an important factor in development of rat radiation pneumonia. |
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