| Li Min,Xiao Jiasi,Yan Shuzi.Changes in intracellular K+ concentration and action potential of myocardiocytes in early stage of radiation, burn and combined radiation-burn injuries in rats[J].Chinese Journal of Radiological Medicine and Protection,1996,16(2):85-87 |
| Changes in intracellular K+ concentration and action potential of myocardiocytes in early stage of radiation, burn and combined radiation-burn injuries in rats |
| Received:November 02, 1994 Revised:April 24, 1995 |
| DOI： |
| KeyWords:Radiation burn combined radiation-burn injury action potential intracellular potassium concentration myocardium rats |
| FundProject: |
| Author Name | Affiliation | | Li Min | Department of Physiology, Third Military Medical College, Changing, 630038 | | Xiao Jiasi | Department of Physiology, Third Military Medical College, Changing, 630038 | | Yan Shuzi | Department of Physiology, Third Military Medical College, Changing, 630038 | | 万子兵 | Department of Physiology, Third Military Medical College, Changing, 630038 |
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| Abstract:: |
| in this experiment K+-ISME and microelectrode were used respectively to measure the [K+]i concentration and action potential in ventricular papillary myocardiocytes of 92 Wistar rats, which were divided into four groups: normal rats (group C).and rats receiving radiation (group R). burn (group B) and combined radiationburn (group RB), and undergoing measurement 1, 3,8 and 24 hours after respective treatment. It was found that (1) [K+]i was reduced in groups B and RB (especially in group B), but there was no change in group R; (2) RP, APA and Vmax were all decreased in three injured groups;(3) APD50 and APD90 were shortened obviously in group B, but were prolonged in both groups R and RB (especially in group R). These results suggest that (1) radiation injury diminishes Na+ inflow and K+ outflow;(2) burn diminishes Na+ inflow and accelerates K+ outflow; (3) combined radiation-burn injury is not a simple addition of radiation and burn effects. |
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