| Du Zeji,Su Liaoyuan,Kong Xiangrong,Tian Hailin.Adaptive response of DNA strand breaks in lymphocytes to low dose and γ-rays[J].Chinese Journal of Radiological Medicine and Protection,1996,16(1):32-34 |
| Adaptive response of DNA strand breaks in lymphocytes to low dose and γ-rays |
| Received:September 10, 1994 Revised:February 23, 1995 |
| DOI： |
| KeyWords:Low dose γ-rays lymphocytes DNA strand breaks adaptive response |
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| Abstract:: |
| Fluorometric analysis of DNA unwinding was used to study the adaptive response of DNA strand breaks induced by low dose γ-rays and the effect of pADPRT inhibitor-3-AB on the adaptive response.The results indicated that 0.5-4 cGy γ-rays could induce adaptive response of DNA strand breaks in lymphocytes, especially at the doses of 2.0 and 4.0 cGy.This response was not obvious after 8.0 cGy γ-rays irradiation.A challenge dose of 5-20 Gy could make the response expressed, 15 Gy was the best one and 30 Gy was too high to give an adaptive response.0.5 mM 3-AB could inhibit the response vigorously.As the concentration increased, the adaptive reaponse could be inhibited completely. |
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