| Luo Chengji,Guo Chaohua,Zhou Yanhong,Liu Xin.Effects of interleukin-3 on hemopoietic function after combined radiation-burn injury in mice[J].Chinese Journal of Radiological Medicine and Protection,1996,16(1):28-31 |
| Effects of interleukin-3 on hemopoietic function after combined radiation-burn injury in mice |
| Received:November 24, 1994 Revised:April 05, 1995 |
| DOI： |
| KeyWords:Interleukin-3 combined radiation-burn injury hematopoietic function |
| FundProject:国家自然科学基金 |
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| Abstract:: |
| Destruction of hemopoietic function is one of the most basic pathologic changes in combined radiation-burn injury.Interleukin-3 exhibits a broad-spectum stimulating effect on proliferation and differentiation for hemopoietic cells.This study was aimed to investigate the effects of interleukin-3 on hmopoietic function after combined radiation-burn injury in mice.The results show that preventing and additionally treating radiation injury or the combined radiation-burn injury with IL-3 have better effects on the stimulation of hematopoiesis in vivo than only preventing or treating with IL-3.This favourable stimulation of hemopoiesis was not only expressed in granulocyte-macrrophage progentors(CFU-GM) or erythroid progenitors(CFU-E, BFU-E), but also in bone marrow stromal elements(CFU-F).Stimulating effect on hemopoiesis was not shown in animals with burn injury in which hemopoietic failures did not appear.The results indicate that excellent prospects are expected by using IL-3 in treating radiation injury or combined radiation-burn injury. |
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