| Zhao Po,Yang Zhixiang,Wang Dewen.A pathological study on overexpression of c-erbB-2,EGFR proteins in human radiation skin ulcer[J].Chinese Journal of Radiological Medicine and Protection,1996,16(1):26-27 |
| A pathological study on overexpression of c-erbB-2,EGFR proteins in human radiation skin ulcer |
| Received:February 11, 1995 Revised:April 06, 1995 |
| DOI： |
| KeyWords:Radiation skin ulcer oncogene epidermal growth factor receptor |
| FundProject:国家自然科学基金;中国博士后科学基金 |
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| Abstract:: |
| We performed an immunohistochemical study in 25 cases of human radiation skin ulcer by using c-erbB-2, Epidermal growth factor receptor(EGFR), protein antibodies and repairing method of antigen with microwave oven.The results show that the positive rate for overexpression of c-erbB-2 oncoprotein was 92.0% (23/25), and EGFR was 73.7% (14/19).The positive position for overexpression of c-crbB-2 was mainly observed on cell memberane of squamous epithelial cells and cell plasma of fibroblasts, endotheliocytes, and leiomyocytes in media and fibrocytes in adventitia of the arterioles in mesenchyme.It is suggested that the overexpression of c-erbB-2 and EGFR proteins might be related to cancer transformation and poor healing in radiation skin ulcers. |
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