| Chen Xian,Hajima Yokota,Takeshi Ohtsuru.In vivo 31P-magnetic resonance spectroscopic studies of radiation hepatitis[J].Chinese Journal of Radiological Medicine and Protection,1996,16(1):21-25 |
| In vivo 31P-magnetic resonance spectroscopic studies of radiation hepatitis |
| Received:October 07, 1994 Revised:July 17, 1995 |
| DOI： |
| KeyWords:31P-magnetic resonance spectroscopy radiation hepatitis |
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| Abstract:: |
| Thirty-five Syrian golden hamsters were divided into 7 groups based on the time interval following irradiation (B to H).Group A served as the control and groups B to H were designated as one day, 2 days, 3 days, 1 week, 4 weeks, 8 weeks and 9 months after irradiation, respectively.The hamster liver received a single 40 Gy dose of radiation using an 8 MeV electron beam.A magnetic field of 6.34 Tesla and 31P-resonance frequency appropriate for the spectrometer.All hamsters were sacrificed and histological specimens were obtained.The ratios of each peak value phosphourus signal to β-ATP obtained from the control group and irradiated groups showed that the peak intensities of the PME was higher in groups B-D, γ-ATP and α-ATP in groups of later than 1 week after irradiation were lower than those of the control group.Intracellular pH value for group B was higher than that for group A,and pH values for groups C and D were lower at once, while pH values for groups E and F were higher again than those for C and D(P<0.05).Histological specimens showed focal lose of hepatocytes, fatty degeneration and hepatocyte atrophy.The authors consider that 31P-MRS is very useful in evaluation of the metabolic changes in radiation hepatitis. |
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