| Wan Hong,Gong Shouliang.Expression of c-fos protooncogene in mouse brain following low dose irradiation[J].Chinese Journal of Radiological Medicine and Protection,1996,16(1):15-17 |
| Expression of c-fos protooncogene in mouse brain following low dose irradiation |
| Received:May 15, 1995 Revised:June 30, 1995 |
| DOI： |
| KeyWords:Low dose radiation protooncogene in situ hybridization |
| FundProject:国家自然科学基金 |
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| Abstract:: |
| In situ hybridization was used to examine the expression of c-fos mRNA in mouse brain following whole body irradiation(WBI) with 75 mGy X-rays.The results showed that WBI with 75 mGy could stimulate the expression of c-fos in extensive areas of neurons in the mouse brain, especially in the cerebral cortex and hypothalamus.The c-fos mRNA appeared 15 min after irradiation, reached its peak within 1 h and began to fade at 2 h with its total disappearance 8 h after irradiation.These findings indicate that low dose radiation can enhance the activity of the neurons in certain areas of the brain. |
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