| Zhu Kang'er,Kerry Atkinson.In vivo effects of interleukin-3(IL-3) and IL-6, alone and in combination with G-CSF,GM-CSF, or IL-1, on platelet count after murine bone marrow transplantation[J].Chinese Journal of Radiological Medicine and Protection,1996,16(1):12-14 |
| In vivo effects of interleukin-3(IL-3) and IL-6, alone and in combination with G-CSF,GM-CSF, or IL-1, on platelet count after murine bone marrow transplantation |
| Received:February 13, 1995 Revised:April 14, 1995 |
| DOI： |
| KeyWords:Interleukin allogeneic bone marrow transplantation hematopoietic reconstitution |
| FundProject:包玉刚中国留学生奖学金资助 |
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| Abstract:: |
| We explored the effect of IL-3 and IL-6, alone and in combination with G-GSF, GMCSF, or IL-1, on platelet recovery in a murine allogeneic bone marrow transplantation model.When used alone, both IL-6 and G-CSF raised platelet count on day 6 post transplantation(312×109/L, P<0.05 and 309×109/L,P<0.01.respectively), compared with control mice(216×109/L ).IL-3 alone resulted in a platelet count of 303×109/L(P>0.05).In combination, only IL-3 with G-CSF significantly increased the day 6 platelet count(328×109/L ). |
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