| Chen Ying,Masahiro Muto,Eiko Kubo,Yoichi Matsuda.Analysis of initial events in radiation-induced lymphomagenesis:investigation of chromosome aberrations including translocations[J].Chinese Journal of Radiological Medicine and Protection,1995,15(6):396-399 |
| Analysis of initial events in radiation-induced lymphomagenesis:investigation of chromosome aberrations including translocations |
| Received:April 27, 1994 Revised:March 13, 1995 |
| DOI： |
| KeyWords:Radiation thymic lymphoma chromosome aberrations |
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| Abstract:: |
| To investigate the contribution of chromosome aberrations in radiation- induced lymphomagenesis, chromosome G-banding analysis of the lymphoma cells(8 groups and 34 kinds of cells),of which each group was derived from a single donor by intrathymic injection of a limited number of prelymphoma cells, was performed.Many numerical and structural aberrations were observed in the donor-derived T cell lymphomas. Common aberrations including translocations were found almost in the lymphomas of all groups.Translocations between chromosomes 11 and 12,12 and 15,7 and 10,1 and 13, 6 and X were found in D, E, F, G,H groups,respectively.There were also common aberrations such as trisomy 15 in A and F groups.These results indicate that chromosome aberrations including translocations may be important candidates of initiating events in radiation-induced lymphomagenesis. |
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