| Sun Xiaoling,Jiang Jie,Wang Ping.Ⅲ Effect of adaptive response in germ cells or embryos on offspring[J].Chinese Journal of Radiological Medicine and Protection,1995,15(5):302-305 |
| Ⅲ Effect of adaptive response in germ cells or embryos on offspring |
| Received:October 18, 1994 Revised:April 03, 1995 |
| DOI： |
| KeyWords:Germ cells embryos ionizing radiation adaptive response |
| FundProject:国家自然科学基金 |
| Author Name | Affiliation | | Sun Xiaoling | Institute of Radiation Medicine, Norman Bethune University of Medical Sciences, Changchun, 130021 | | Jiang Jie | Institute of Radiation Medicine, Norman Bethune University of Medical Sciences, Changchun, 130021 | | Wang Ping | Institute of Radiation Medicine, Norman Bethune University of Medical Sciences, Changchun, 130021 | | 王献理 | Institute of Radiation Medicine, Norman Bethune University of Medical Sciences, Changchun, 130021 | | 蔡露 | Institute of Radiation Medicine, Norman Bethune University of Medical Sciences, Changchun, 130021 |
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| Abstract:: |
| The characteristics of the adaptive response induced by radiationin mouse germ cells or embryos were studied. The results showed that single irradiation of mouse germ cells with 50mGy X-rays could reduce the dominant lethality caused by a subsequent large dose. In male mouse germ cells, subacute irradiation with X-rays (50mGy×4) or chronic irradiation with γ-rays (accumulated doses of 1.10Gy) also induced a significant cytogeuetic adaptive response, but this response had no influence on the chromosome damage in offspring germ cells, bone marrow cells and DNA repair (UDS) in offspring splenic cells.These results indicate that the adaptive response induced by low dose irradiation in germ cells could not be transferred to descendants.Contrary to the case of germ cells,chronic irradiation of mouse embryos with low dose γ-rays could make the mature mouse offspring show a significant resistance to chromosome damage induced by ionizing radiation. |
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