| Meng Qingyong,Jiang Jie,Cai Lu.ⅡCross-resistance to ionizing radiation and to chemical mutagens[J].Chinese Journal of Radiological Medicine and Protection,1995,15(5):298-301 |
| ⅡCross-resistance to ionizing radiation and to chemical mutagens |
| Received:October 18, 1994 Revised:April 08, 1995 |
| DOI： |
| KeyWords:Adaptive response chemical mutagens ionizing radiation Mice germ cells |
| FundProject:国家自然科学基金 |
| Author Name | Affiliation | | Meng Qingyong | Institute of Radiation Medicine, Norman Bethune University of Medical Scineces, Changchun, 130021 | | Jiang Jie | Institute of Radiation Medicine, Norman Bethune University of Medical Scineces, Changchun, 130021 | | Cai Lu | Institute of Radiation Medicine, Norman Bethune University of Medical Scineces, Changchun, 130021 | | 金玉珂 | Institute of Radiation Medicine, Norman Bethune University of Medical Scineces, Changchun, 130021 |
|
| Hits: 2592 |
| Download times: 1425 |
| Abstract:: |
| In this study, the cross-adaptive response to radiation and to chemical mutagens (mitomycin C, H2O2 ,cyclophosphamide)was observed in vivo in mouse germ cells. The results showed that low concentration of mitomycin C (0.1, 0.5mg/kg) and H2O2, (0.02, 0.05 mol/L) could reduce the frequency of chromosome aberration in mouse germ cells in vivo caused by subsequent irradiation (1.5 Gy X-rays);and 50 mGy X-rays also made the cells have a resistance to chromosome damage by high concentration mitomycin C (3.0, 5.0 mg/kg) and H2O2 (0.5 and 1.5 mol/L) .Contrary to those mentioned above, low concentration of cyclophosphamide (0.5, 1.0 mg/kg)made the germ cells more susceptible to induction of chromosome aberration by ionizing radiation, and at the same time,low dose radiation also made the cells more susceptible to the chromosome damage by high concentration cyclophosphamide (25, 40 mg/kg) .These results indicate that there is a cross-resistance to ionizing radiation and to DNA cross-linking agents (mitomycin C) and DNA oxidizing agents (H2O2) , but there is no cross-resistance to radiation and to alkylating agents (cyclophosphamide ).All these results provide some important materials for elucidating the mechanism of the adaptive response induced by ionizing radiation. |
| HTML View Full Text View/Add Comment Download reader |
| Close |
|
|
|
