| Liu Guolian,Tu Kaicheng,Cao Zhenshan.Morphometric study of transformed cells in vitro by ionizing radiation[J].Chinese Journal of Radiological Medicine and Protection,1995,15(3):169-174 |
| Morphometric study of transformed cells in vitro by ionizing radiation |
| Received:September 05, 1994 Revised:January 13, 1995 |
| DOI： |
| KeyWords:image analysis system ionizing radiation cell transformation morphometric parameters |
| FundProject:国家自然科学基金 |
| Author Name | Affiliation | | Liu Guolian | Institute of Radiation Medicine,Beijing, 100850 | | Tu Kaicheng | Institute of Radiation Medicine,Beijing, 100850 | | Cao Zhenshan | Institute of Radiation Medicine,Beijing, 100850 | | 周淑珍 | Institute of Radiation Medicine,Beijing, 100850 | | 祝霄霞 | Institute of Radiation Medicine,Beijing, 100850 | | 杨素霞 | Institute of Radiation Medicine,Beijing, 100850 | | 樊飞跃 | Institute of Radiation Medicine,Beijing, 100850 | | 吴德昌 | Institute of Radiation Medicine,Beijing, 100850 |
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| Abstract:: |
| The morphometric changes in transformed cells and nuclei of human embryo lung cells or Wistar rat lung fibroblasts in vitro post irradiation with 60Co gamma rays or 238Pu alpha particles was observed by image analysis system and their dose-responsa relation were studied.The results showed that the biological characteristics and changes of morphometric parameters in transformed cells induced by two types of radiation were basically similar.The parametets of area,equivalent diameter in cells or nuclei and ratio of nucleus to plasma increased with increasing radiation dose.It was expressed by model of linear square:E=a+bD+cD2.These parameters were not only related to radiation doses,but also dependent on the number of cell passaaes after transformation. |
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