| Su Xu,Zhang Yingchun,Liu Shuzheng.Effects on subsets of thymic lymphocytes after X-irradiation with different doses[J].Chinese Journal of Radiological Medicine and Protection,1995,15(2):103-105 |
| Effects on subsets of thymic lymphocytes after X-irradiation with different doses |
| Received:April 27, 1994 Revised:July 19, 1994 |
| DOI： |
| KeyWords:Gamma radiation T subsets flow cytometry |
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| Abstract:: |
| Kunming Mice were whole-body irradiated with 0.5,1.0,2.0and 4.0 Gy X-rays.The thymic lymphocytes were analyzed by flow cytometry with fluorecscent monoclonal antibodies 24 hours after irradiation.It was found that the percentages of CD4+CD8-,GD4-CD8+ and CD4-CD8- cells increased in varying degrees,while the percentage of CD4+CD8+ cells showed a dose -dependent decrease.However,the absolute number of total thymic lymphocytes and the subsets decreased.The absolute number of CD4+CD8+ cells decreased more markedly than that of other subsets.These observations suggest that the radiosensitivity varied in different stages of differentiations of.the thymocytes.The order of radiosensitivity was:CD4+CD8+>CD4-CD8->CD4-CD8+> CD4+CD8-. |
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