| Li Yu,Zhao Fang,Zhao Lan.Radiosensitizing effect of metronidazole amino acid sodium on hemopoietic cells of mouse bone marrow[J].Chinese Journal of Radiological Medicine and Protection,1995,15(2):96-98 |
| Radiosensitizing effect of metronidazole amino acid sodium on hemopoietic cells of mouse bone marrow |
| Received:June 20, 1994 Revised:September 12, 1994 |
| DOI： |
| KeyWords:Radiosensitizer metronidazole amino acid sodium CFU-GM.CFU-S |
| FundProject:国家新药研究与开发基金 |
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| Abstract:: |
| The radiosensitizing effect of a new radiosensitizer,metronidazoleamino acid sodium(CMNa),on hemopoietic cells of mouse bone marrow was studied by counting the numbers of colony forming units of granulocytes and macrophages(CFU-GM ) and of spleen(CFU-S) in vivo or in vitro.The results showed that there was no inhibition on formation of CFU-GM and CFU-S when the CMNa was administered at the dosage of 0-1 000mg/kg(ip,twice a week,for 4 weeks).Under our irradiation conditions(0-6 Gy),the forming rate of CF U-GM was not statistically significantly different between irradiation group and irradiation plus CMNa group(200 mg/kg,ip,twice a week for two weeks).These results suggest that CMNa does not induce more radiosensitivity to hemopoietic cells. |
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