| Ma Enpu,Bi Jianjin,Zhang Aiqin.Experimental study on therapy of acute radiation sickness with transplantation of allogeneic peripheral blood hemopoietic stem cells[J].Chinese Journal of Radiological Medicine and Protection,1995,15(2):88-92 |
| Experimental study on therapy of acute radiation sickness with transplantation of allogeneic peripheral blood hemopoietic stem cells |
| Received:July 08, 1994 Revised:September 22, 1994 |
| DOI： |
| KeyWords:Circulating blood hemopoietic stem cells allogeneic transplantation acute radiation sickness therapy |
| FundProject: |
| Author Name | Affiliation | | Ma Enpu | Beijing Institute of Radiation Medicine, Beijing, 100850 | | Bi Jianjin | Beijing Institute of Radiation Medicine, Beijing, 100850 | | Zhang Aiqin | Beijing Institute of Radiation Medicine, Beijing, 100850 | | 郭春义 | Beijing Institute of Radiation Medicine, Beijing, 100850 | | 郑再兴 | Beijing Institute of Radiation Medicine, Beijing, 100850 | | 黎文亮 | Beijing Institute of Radiation Medicine, Beijing, 100850 | | 刘秀林 | Beijing Institute of Radiation Medicine, Beijing, 100850 | | 刘秀英 | Beijing Institute of Radiation Medicine, Beijing, 100850 | | 宋春奎 | Beijing Institute of Radiation Medicine, Beijing, 100850 | | 吴祖泽 | Beijing Institute of Radiation Medicine, Beijing, 100850 |
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| Abstract:: |
| In the study,10 beagles were used. All the dogs were irradiated with 6.5 Gy of γ-rays from a 60Co source(dose rate,95.6-107.9 R/min) and divided into three groups.All the three dogs in the control group died,having survived 7.5 days on the average after irradiation.In the second group,four dogs were transplanted with allogeneic peripheral blood hemopoietic stem cells(PBHSC) without removing T lymphocytes.The results of sex chromosome tests after irradiation and transplantation showed that the cells were of donor type.All the four dogs died of severe graft-versus-host disease(GVHD) and survived 41.6 days on the average after irradiation.In the third group, three dogs received transplantation of allogeneic PBHSC without T lymphocytes.Two of them died,and the third developed mild GVHD and survived over 4 years. |
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