| Bai Yushu,Huang Qilong,Guan Shurong,et al.Application of cytokinesis-block micronuleus method in radiation accident in Xinzhou City of Shanxi Province[J].Chinese Journal of Radiological Medicine and Protection,1995,15(2):75-79 |
| Application of cytokinesis-block micronuleus method in radiation accident in Xinzhou City of Shanxi Province |
| Received:June 20, 1994 Revised:August 24, 1994 |
| DOI： |
| KeyWords:Cytokinesis-block micronucleus method chromosome aberrations.radiation accident biological dose |
| FundProject: |
| Author Name | Affiliation | | Bai Yushu | Laboratory of Industrtal Hygiene, Ministry of Health, Beijing, 100088 | | Huang Qilong | Laboratory of Industrtal Hygiene, Ministry of Health, Beijing, 100088 | | Guan Shurong | Laboratory of Industrtal Hygiene, Ministry of Health, Beijing, 100088 | | 柴文 | Laboratory of Industrtal Hygiene, Ministry of Health, Beijing, 100088 |
|
| Hits: 3629 |
| Download times: 1947 |
| Abstract:: |
| This paper reports a radiation accident on November 19,1992in Xinzhou City of Shanxi Province,China.A woman patient,aged 24,with undetermined history of radiation exposure, was proved to have been exposed to high dose irradiation in the light of chromosome aberrations in peripheral lymphocytes.The absorbed dose estimated based on the frequency of dicentrics plus rings was equivalent to 2.30 Gy of homogeneous whole body irradiation with the 95% confidence limit of 2.07-2.50 Gy. With this diagnosis,the following advice was offered:(1)immediate search for the radiation source with a view to eradicating as soon as possible the menace to the safety and health of local inhabitants;(2) medical surveillance of potentially irradiated people. estimation of exposure dose,and taking proper measures;and(3) appropriate treatment of the patient.After energetic effort,an abandoned sealed 60Co source was at last found.At the 38-70th days after the accident,the frequencies of chromosome aberrations and micronuclei were examined by cytokinesis-block micronucleus method for 34 individuals.Exposure doses were estimated by using the cytogenetic technique.The results of micronucleus and dicentric plus ring assays were similar,so that CB micronucleus method can be used for estimating exposure dose to individuals. |
| HTML View Full Text View/Add Comment Download reader |
| Close |
|
|
|
