| Tao Laibao,Chen Jiapei.Granulopoietic activity in mouse serum and its changes after irradiation[J].Chinese Journal of Radiological Medicine and Protection,1995,15(1):20-23 |
| Granulopoietic activity in mouse serum and its changes after irradiation |
| Received:March 22, 1994 Revised:May 24, 1994 |
| DOI： |
| KeyWords:Granulopoietic activity γ-irradiation stimulating factors CFU-GM |
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| Abstract:: |
| Using the method of colony formation of CFU-GM, granulopoietic activity in mouse serum was estimated. The experimental results showed that normal mouse serum was capable of stimulating the growth of CFU-GM. This stimulant activity elevated at 7-10th days after irradiation with 8 Gy γ-rays, and the maximal level was 140% of normal serum. At the 14th day post exposure, the increased stimulant acivity tended to decrease. The changes of stimulant granulopoietic activity was also seen in mice irradiated with 3,5,7,9 Gy γ-rays. The activity rose with the increasing radiation doses and might last to the 12th day after irradiation. Meanwhile, there was increased inhibitory granulopoietic activity in irradiated mouse serum, especially by 10 days post exposure.The significance of the variation of serum stimulant and inhibitory activities after radiation and its importance in the development of hemopoietic injuries caused by radiation are discussed. |
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