| Lu Qiujun,Huang Shafei,Zhou Xipeng.Effect of Zi Gui decoction on immune function in 60Co γ-ray irradiated mice[J].Chinese Journal of Radiological Medicine and Protection,1995,15(1):17-19 |
| Effect of Zi Gui decoction on immune function in 60Co γ-ray irradiated mice |
| Received:January 04, 1994 Revised:April 21, 1994 |
| DOI： |
| KeyWords:Zi Gui decoction γ-ray irradiation T and B lymphocyts proliferation IL-2 IL-2 natural killer cells |
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| Abstract:: |
| Zi Gui decoction(ZG), a complex preparation of traditional Chinese herbal medicine, consists mainly of Radix Angelicae and Radix Astragali. We investigated the effects of ZG on mitogen induced proliferation, IL-1 and -2 production, natural killer(NK) cell activity in 60Co γ-ray irradiated mice.After 5 Gy whole body irradiation, mice were treated i.g. with ZG( 1-2, 1.8g/kg/day) for 20 days. An enhancement in Con A-and LPS-induced proliferations of splenocytes from the two dosage groups were observed. There were marked increses in IL-1 activity in peritoneal macrophage culturesa and IL-2 activity in splenocyte cultures from irradiated mice treated wtih ZG. The two dosage groups also showed significant potentiation of NK cell activity against YAC-1 target cells.The above results indicated that ZG could promote the recovery of immune functions in γ-ray irradiated mice. |
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