| Wang Jianfeng,Ge Zhongliang,Liu Xuetong.Studies on the heterogeneity and radiosen-sitivity of CFU-S[J].Chinese Journal of Radiological Medicine and Protection,1990,10(4):226-229 |
| Studies on the heterogeneity and radiosen-sitivity of CFU-S |
| Received:September 23, 1988 |
| DOI： |
| KeyWords:CFU-S heterOgeneity radiosensitivny |
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| Abstract:: |
| Mice irradiated with 8.5 Gy were in-jected with bone marrow cells obtained from normal(NBM) or 3 Gy irradiated (IBM)donors.At various intervals(7-13 days)after injection, groups of mice were killed and spleen colohies were count-ed.It was found that the colonies increas-ed in ntmabcr exponentially from days 7 to 9, decreased from days 9 to 11 and increased again from days 11 tol3 in NBM group.In IBM group, the increase of colonies from days 7 to 9 was more pronounced than that of NBM, but no apparent difference was observed from dags 9 to 1 3.The morpholo-gical analysis showed that 50%of d 8 colonies was erythrOpOietic type in NBM, only 27.7% in IBM, d 13 colonies were predominantly mixed type both in NBM (57.7%)and IBM(50.7%).Further stud-ies demonstrated that the radiosensitivity of d 8 CFU-S was significantly higher than that of d 13 CFU-S with D0 values of 1.48 and 1.09 Gy respectively.The pattern of recovery of d 8 CFU-S in the bone marrow of mice following 3 Gy total body irradiation was similar to that of d 13 CFU-S. All these results indicate that CFU-S is a heterogenous population, and it is supposed that there probably exists a highly radio-sensitive subpopulation in d 7-9 CFU-S with commitment to erythropOietic lineage. |
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