| Zhao Naikun,Du Weixia,Liu Xiumin,Jiang Hanying,Zhang Jihui.ESTABLISHMENT OF CELL LINES OF RADIATION-INDUCED MYELOCYTIC LEUKEMlA IN LACA MlCE AND THEIR BIOLOGlCAL PROPERTIES[J].Chinese Journal of Radiological Medicine and Protection,1981,1(5):7-12 |
| ESTABLISHMENT OF CELL LINES OF RADIATION-INDUCED MYELOCYTIC LEUKEMlA IN LACA MlCE AND THEIR BIOLOGlCAL PROPERTIES |
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| Author Name | Affiliation | | Zhao Naikun | Department of Biological Effect of Radiation, Laboratory of Industrial Hygiene, Ministry of Public Health, Beijing | | Du Weixia | Department of Biological Effect of Radiation, Laboratory of Industrial Hygiene, Ministry of Public Health, Beijing | | Liu Xiumin | Department of Biological Effect of Radiation, Laboratory of Industrial Hygiene, Ministry of Public Health, Beijing | | Jiang Hanying | Department of Biological Effect of Radiation, Laboratory of Industrial Hygiene, Ministry of Public Health, Beijing | | Zhang Jihui | Department of Biological Effect of Radiation, Laboratory of Industrial Hygiene, Ministry of Public Health, Beijing |
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| Abstract:: |
| Suspensions of spleen cells from LACA mice with radiation-induced myelocytic leukemia were given intravenously to mice of the same strain.and transplantable myelocytic leukemia was established.Gradually.the tumor cell lines became sta ble.grew rapidly and obtained greater malignancy through 50 serial passages.The latent period was shortened from 1～2 months at the beginning to 1～2 weeks recently.With an average of 11.31±4.1 days.The incidence of transplanted myelocytic leukemia averaged 78.5 per cent.The average number of white cells in peripheral blood was 22.420±12.360/mm3.They were positive to the peroxidase reaction. More than 90 per cent of the chromosomes of leukemic cells were hypodiploid.And 94 per cent of the leukemic cells were deprived of Y chromosomes. Now.we are able to transplant the leukemic lines in LACA mice without any pretreatment. |
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