| 戴宏,刘玉龙,王优优,冯骏超,赵骅,刘青杰,郭凯琳.南京“5.7” 192Ir源放射事故患者的生物剂量估算[J].中华放射医学与防护杂志,2016,36(5):350-354 |
| 南京“5.7” 192Ir源放射事故患者的生物剂量估算 |
| Biological dosimetry for the victim accidentally exposed to 192Ir radiation source at “5.7” accident in Nanjing |
| 投稿时间：2016-02-05 |
| DOI：10.3760/cma.j.issn.0254-5098.2016.05.008 |
| 中文关键词: 192Ir辐射事故 生物剂量估算 染色体畸变 微核 核质桥 |
| 英文关键词:192Ir radiation accident Biological dose estimation Chromosomal aberrations Micronuclei Nucleoplasmic bridges |
| 基金项目:江苏省临床医学科技专项(BL2014040);江苏省卫生计生委2014-2015年度预防医学科研项目(Y2015024);江苏省研究生培养创新工程项目(SJLX15-0580) |
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| 中文摘要: |
| 目的 用3种方法估算南京"5.7" 192Ir源放射事故患者的生物剂量,为核与辐射事故受照者的临床救治提供剂量资料。方法 受照后第5天采集患者外周血,分别进行外周血淋巴细胞染色体"双着丝粒+环"("dic+r")畸变分析、胞质分裂阻滞微核(CBMN)分析、核质桥(NPB +FHC)分析,并估算生物剂量。用双着丝粒畸变在细胞间的泊松分布情况检验照射的均匀性。结果3种方法估算的该患者受到的一次全身等效剂量分别为"dic+r"畸变分析1.51 Gy (95% CI 1.40~1.61),CBMN 分析1.47 Gy (95% CI 1.36~1.60),NPB+FHC分析1.30 Gy(95% CI 1.00~1.60)。泊松分布检验结果显示,该患者"dic+r"畸变偏离泊松分布,受到了不均匀照射。结论 外周血淋巴细胞染色体"dic+r"畸变分析、CBMN分析、NPB+FHC分析均是有效的生物剂量估算手段,对本例急性局部不均匀照射患者估算的一次全身等效剂量与临床诊断结果相符。 |
| 英文摘要: |
| Objective To use three different methods in attempt to estimate the biological dose of the patient partially exposed to 192Ir source at "5.7" accident in Nanjing, so as to provide dosimetric information for clinical remedy of exposed patients in the emergency of a nuclear accident. Methods Peripheral blood samples were collected on days 5 after exposure. The biological dose was estimated by the yields of dicentrics plus rings ("dic+r"), cytokinesis-block micronuclei (CBMN) assay and nucleoplasmic bridge plus FHC (NPB+FHC). The homogeneity of radiation exposure was examined by Poisson distribution of dicentrics. Results By using three different methods, the whole body equivalent dose was "dic+r" estimated to be 1.51 Gy (95%CI 1.40-1.61), 1.47 Gy (95%CI 1.36-1.60) by CBMN and 1.30 Gy (95%CI 1.00-1.60) by NPB+FHC, respectively. A non-poisson distribution was also detected, suggesting partial body radiation exposure. Conclusions The estimated whole body equivalent dose of a non-uniform radiation exposure was consistent with clinical diagnosis, suggesting that the yields of "dic+r", CBMN, as well as NPB+FHC, are efficient approaches to the estimation of biological doses. |
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