| 戴李宸,顾大勇,于静萍.体部立体定向放射治疗联合免疫检查点抑制剂在食管癌寡转移的临床应用进展[J].中华放射医学与防护杂志,2026,46(7):712-720.Dai Lichen,Gu Dayong,Yu Jingping.Advances in the clinical application of stereotactic body radiotherapy combined with immune checkpoint inhibitors for oligometastatic esophageal cancer[J].Chin J Radiol Med Prot,2026,46(7):712-720 |
| 体部立体定向放射治疗联合免疫检查点抑制剂在食管癌寡转移的临床应用进展 |
| Advances in the clinical application of stereotactic body radiotherapy combined with immune checkpoint inhibitors for oligometastatic esophageal cancer |
| 投稿时间：2025-09-04 |
| DOI：10.3760/cma.j.cn112271-20250904-00316 |
| 中文关键词: 体部立体定向放射治疗 免疫检查点抑制剂 食管癌 寡转移 |
| 英文关键词:Stereotactic body radiotherapy Immune checkpoint inhibitor Esophageal cancer Oligometastasis |
| 基金项目:上海市卫健委临床面上项目(202340160);常州市卫健委科技前沿技术项目(QY202404);南京医科大学常州医学中心项目(CMCC202411) |
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| 中文摘要: |
| 食管癌是我国发病率较高的恶性肿瘤,其寡转移状态介于局限性病变与广泛转移之间,近年来被认为是临床干预的重要窗口。目前,免疫检查点抑制剂(ICIs)已成为晚期食管癌的一线标准治疗手段,但患者的临床获益仍然有限。体部立体定向放射治疗(SBRT)具有高精度与高剂量的特点,不仅可实现对食管癌寡转移灶的局部控制,还能够诱导全身性的抗肿瘤免疫应答,二者具有协同效应,因此,其与免疫治疗的联合应用模式正成为研究热点。本综述聚焦于SBRT联合ICIs在食管癌寡转移治疗领域的最新进展,涵盖该疾病定义的演变、潜在的协同机制以及相关研究等,旨在为临床应用提供有价值的参考。 |
| 英文摘要: |
| Esophageal cancer is a highly prevalent malignant tumor in China. Its oligometastatic state lies between localized disease and extensive metastasis, and has been regarded as an important window for clinical intervention in recent years. Currently, immune checkpoint inhibitors (ICIs) have become the first-line standard treatment for advanced esophageal cancer, but the clinical benefits for patients remain limited. Stereotactic body radiotherapy (SBRT) is characterized by high precision and high dose, which can not only achieve local control of oligometastatic lesions in esophageal cancer but also induce systemic antitumor immune responses. The two have a synergistic effect, and thus the combined application mode of SBRT and immunotherapy is becoming a research hotspot. This review focuses on the latest progress of SBRT combined with ICIs in the treatment of oligometastatic esophageal cancer, covering the evolution of the disease definition, potential synergistic mechanisms, and relevant studies, aiming to provide valuable references for clinical practice. |
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