| 林华,李莉,苏鸣岗,等.Q.Clear在 68Ga-Pentixafor PET/MR肾上腺显像中降低放射性药物剂量的可行性研究[J].中华放射医学与防护杂志,2026,46(5):458-463.Lin Hua,Li Li,Su Minggang,et al.Feasibility of Q.Clear reconstruction algorithm in reducing radiopharmaceutical dose for adrenal 68Ga-Pentixafor PET/MR imaging[J].Chin J Radiol Med Prot,2026,46(5):458-463 |
| Q.Clear在 68Ga-Pentixafor PET/MR肾上腺显像中降低放射性药物剂量的可行性研究 |
| Feasibility of Q.Clear reconstruction algorithm in reducing radiopharmaceutical dose for adrenal 68Ga-Pentixafor PET/MR imaging |
| 投稿时间：2026-02-25 |
| DOI：10.3760/cma.j.cn112271-20260225-00063 |
| 中文关键词: Q.Clear PET/MR 肾上腺 放射性药物剂量 图像重建 |
| 英文关键词:Q.Clear PET/MR Adrenal gland Radiopharmaceutical dose Image reconstruction |
| 基金项目:国家重点研发计划项目(2023YFC2414201-1) |
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| 中文摘要: |
| 目的 与有序子集最大期望值算法(OSEM)对比,探讨贝叶斯惩罚似然重建算法(Q.Clear)结合低剂量放射性药物在肾上腺镓-68-喷替沙福正电子发射断层显像/磁共振成像(68Ga-Pentixafor PET/MR)图像质量和辐射剂量的研究。方法 回顾性纳入在四川大学华西医院接受68Ga-Pentixafor PET/MR检查的原发性醛固酮增多症患者35例,注射剂量为(142.3 ± 38.5) MBq,采集时间为6 min/床位,通过数据分割模拟不同采集时间(1、1.5、2、3、6 min/床位),分别对应16.7%、25%、33.3%、50%及100%全剂量,行Q.Clear (β=1 000)和OSEM图像重建,比较两种算法图像噪声、病灶显示、整体质量等主观评分以及标准摄取值(SUV)、病灶体积(LV)、病灶背景比(L/B)、信噪比(SNR)和背景噪声(SD)等客观指标。结果 主观评价显示Q.Clear在2 min及以上采集时间均达到临床诊断标准(≥3分)。客观参数显示,与OSEM相比,Q.Clear在各时间组均表现出更优的噪声抑制能力,且2 min Q.Clear的SNR[60.50(44.62,86.97)]、L/B[11.17(8.60,15.72)]和SD[0.24(0.18,0.34)]与6 min OSEM的SNR[57.55(39.26,80.06)]、L/B[11.84(7.23,13.19)]、SD[0.28(0.19,0.35)]之间差异无统计学意义(P>0.05)。结论 保持6 min/床位采集时间,采用33.3%放射性药物剂量,Q.Clear可获得满足临床诊断的图像质量,为制定低剂量扫描方案提供了依据,有助于推动肾上腺肿瘤精准诊疗的辐射安全。 |
| 英文摘要: |
| Objective To explore the feasibility of Bayesian penalized likelihood reconstruction algorithm (Q.Clear) combined with low-dose radiopharmaceuticals in adrenal gallium-68-pentixafor positron emission tomography/magnetic resonance (68Ga-Pentixafor PET/MR), in comparison with ordered subset expectation maximization (OSEM) algorithm, in terms of image quality and radiation dose. Methods A total of 35 patients with primary aldosteronism who underwent 68Ga-Pentixafor PET/MR at West China Hospital of Sichuan University were retrospectively enrolled. The mean injected dose was (142.3 ± 38.5) MBq. Data were acquired for 6 min per bed position and subsequently partitioned to simulate shorter acquisition times(1, 1.5, 2, 3, and 6 min/bed), corresponding to 16.7%, 25%, 33.3%, 50%, and 100% of the full dose, respectively. Images were reconstructed using both Q.Clear(β=1 000) and OSEM.Subjective assessments included image noise,lesion clarity,and overall image quality scores. Objective metrics encompassed standardized uptake values (SUVmax, SUVmean), lesion volume (LV), signal-to-noise ratio(SNR), lesion-to-background ratio(L/B) and background noise(SD). Results Subjective assessments showed that Q.Clear achieved diagnostic-quality images (score ≥3) in acquisition time groups of 2 min or longer;however, the 2 min-group exhibited increased noise compared to longer acquisitions. Analysis of objective parameters revealed superior noise suppression with Q.Clear across all time groups compared to OSEM(P<0.05)Notably, no significant differences were observed between Q.Clear at 2 min and OSEM at 6 min in SNR[60.50 (44.62, 86.97) vs.57.55 (39.26, 80.06)], L/B[11.17 (8.60, 15.72) vs.11.84 (7.23, 13.19)] or SD[0.24 (0.18, 0.34) vs. 0.28 (0.19, 0.35)]. Conclusions Maintaining a 6-minute acquisition time per bed position with 33.3% injected radiopharmaceutical dose and Q.Clear reconstruction provides sufficient image quality for clinical diagnosis.This finding supports the development of low-dose scanning protocols and contributes to radiation safety in precision diagnosis and treatment of adrenal tumors. |
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