| 曹志飞,杜小波.FLASH放疗:从基础研究到临床转化的革命性探索[J].中华放射医学与防护杂志,2025,45(11):1047-1051.Cao Zhifei,Du Xiaobo.FLASH radiotherapy: pioneering the revolutionary path from bench to bedside[J].Chin J Radiol Med Prot,2025,45(11):1047-1051 |
| FLASH放疗:从基础研究到临床转化的革命性探索 |
| FLASH radiotherapy: pioneering the revolutionary path from bench to bedside |
| 投稿时间：2025-09-16 |
| DOI：10.3760/cma.j.cn112271-20250916-00334 |
| 中文关键词: FLASH放疗 超高剂量率 肿瘤 |
| 英文关键词:FLASH Radiotherapy Ultra-high dose rate Tumors |
| 基金项目:国家自然科学基金(12575369,12275192);中核集团青年英才项目 |
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| 中文摘要: |
| 超高剂量率放疗(剂量率≥40 Gy/s)以其独特的"FLASH效应"引领放射肿瘤学革新, 在高效杀灭肿瘤的同时显著减轻正常组织损伤。本期汇集最新研究, 从多维度揭示其生物学机制:在分子层面, FLASH通过差异调控内质网应激、细胞周期阻滞、程序性细胞死亡及能量代谢重编程实现靶向杀伤;FLASH照射可能通过瞬时耗氧形成乏氧窗口, 使正常组织高效清除自由基;多项动物实验证实, FLASH能显著减轻急性与远期放射损伤, 并有效抑制肿瘤生长。物理与剂量学技术的研究解决超高剂量率精准实施与测量的核心挑战, 以期为临床转化扫清障碍。FLASH放疗从机制探索到技术攻坚已奠定坚实根基, 其临床转化进程亟待高质量规范化研究的深入推进, 最终目标是将这一极具前景的FLASH效应安全、精准地应用于患者, 实现肿瘤放疗疗效与生存质量的跨越式提升。 |
| 英文摘要: |
| Ultra-high dose rate radiotherapy (dose rate ≥40 Gy/s), spearheading a revolution in radiation oncology through its unique "FLASH effect", demonstrates remarkable efficacy in eradicating tumors while concomitantly mitigating damage to normal tissues. This special issue compiles cutting-edge research, offering multi-dimensional insights into its biological mechanisms. At the molecular level, FLASH achieves targeted tumor killing by differentially regulating endoplasmic reticulum stress, cell cycle arrest patterns, programmed cell death, and energy metabolism reprogramming. FLASH irradiation may induce a transient oxygen depletion, creating a hypoxic window that facilitates the efficient scavenging of free radicals within normal tissues. Various animal studies have consistently validated FLASH's capacity to significantly alleviate both acute and long-term radiation injuries while potently suppressing tumor growth. Concurrently, advancements in physics and dosimetry have addressed the core challenges of precise delivery and measurement of ultra-high dose rates, in order to clear critical hurdles for clinical translation. In summary, FLASH radiotherapy has established a solid foundation, spanning from mechanistic elucidation to technological innovation. Its clinical translation now urgently demands the advancement of high-quality, standardized research, with the ultimate goal of safely and precisely harnessing the highly promising FLASH effect for patient benefit, thereby achieving a transformative leap in both therapeutic efficacy and quality of life for cancer patients undergoing radiotherapy. |
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