| 吴岱,羊奕伟,张毅,等.X射线FLASH放射治疗的射线来源、计量与防护研究现状[J].中华放射医学与防护杂志,2025,45(11):1041-1046.Wu Dai,Yang Yiwei,Zhang Yi,et al.Current status of radiation sources, meterage and protection in X-ray FLASH radiotherapy[J].Chin J Radiol Med Prot,2025,45(11):1041-1046 |
| X射线FLASH放射治疗的射线来源、计量与防护研究现状 |
| Current status of radiation sources, meterage and protection in X-ray FLASH radiotherapy |
| 投稿时间：2025-10-24 |
| DOI：10.3760/cma.j.cn112271-20251024-00370 |
| 中文关键词: FLASH放射治疗 X射线 射线源 剂量学 |
| 英文关键词:FLASH radiotherapy X-rays Radiation sources Dosimetry |
| 基金项目:国家自然科学基金(12375318) |
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| 中文摘要: |
| 国际上诸多研究表明, 电子线、X射线、质子和重离子都可以用于超高剂量率放疗, 其中MV级X 射线超高剂量率放疗具有广阔的临床前景。中国工程物理研究院应用电子学研究所基于其在强脉冲射线源领域多年的研究积累, 在全球率先解决了兆伏级超高剂量率X射线的产生和计量(剂量测量)难题, 助力中国走在相关领域的国际前列。本文主要介绍超高剂量率X射线产生、计量和防护领域的发展历程、现状和未来趋势。这些数据将为研究人员在临床和临床前试验、设备研发和标准制定等多个方面提供可靠的参考, 以便实现更精确、更可靠的超高剂量率兆伏级X射线产生和计量, 期望对超高剂量率放疗技术的深入研究和临床应用提供支持。 |
| 英文摘要: |
| International studies have established that electrons, X-rays, protons, and heavy ions can all be utilized in ultra-high dose-rate radiotherapy. Among these modalities, megavoltage X-ray ultra-high dose-rate radiotherapy holds particularly broad clinical promise. With its long-term expertise in high-intensity pulsed radiation sources, the Institute of Applied Electronics at the China Academy of Engineering Physics has pioneered global solutions for generating and measuring megavoltage X-rays ultra-high dose-rate radiotherapy, positioning China at the forefront of this field. Herein, we review the development history, current status, and future trends in ultra-high dose-rate X-ray generation, measurement, and protection. The insights provided aim to serve as a reliable reference for clinical and preclinical research, equipment development, and standardization, thereby enabling more precise and reliable megavoltage ultra-high dose-rate X-ray production and measurement. We hope this work will significantly support further research and clinical translation of ultra-high dose-rate radiotherapy technology. |
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