| 华建忠,董娟聪,党旭红,等.放射损伤救治中纳米材料的应用及研究现状[J].中华放射医学与防护杂志,2025,45(10):1032-1040.Hua Jianzhong,Dong Juancong,Dang Xuhong,et al.Application and progress of nanomaterials in the treatment of radiation injury[J].Chin J Radiol Med Prot,2025,45(10):1032-1040 |
| 放射损伤救治中纳米材料的应用及研究现状 |
| Application and progress of nanomaterials in the treatment of radiation injury |
| 投稿时间：2025-03-25 |
| DOI：10.3760/cma.j.cn112271-20250325-00108 |
| 中文关键词: 纳米材料 放射损伤 促排 |
| 英文关键词:Nanomaterials Radiation injury Decorporation |
| 基金项目:中核集团领创科研项目(JT23010201) |
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| 中文摘要: |
| 核技术在工业、医学等领域的应用, 使人们受到放射损伤的可能性随之增加。尽管一些放射损伤救治的小分子药物已应用于临床或处于临床前研究阶段, 但血液循环时间短和新陈代谢速度快, 极大地削弱了其救治效果。放射损伤救治纳米材料因其卓越的生物活性、化学稳定性、组织相容性和靶向递送能力日益受到关注, 有望弥补现有放射损伤救治小分子药物的不足。但其生物安全性和临床疗效仍需深入研究。本综述总结了放射损伤救治纳米材料的设计策略及分类, 分析了应用纳米材料进行救治的研究现状, 介绍了放射性核素内污染的纳米促排疗法, 最后讨论了纳米材料用于放射损伤救治所面临的挑战和未来前景。本综述旨在帮助研究者更好地了解纳米材料在放射损伤救治中的研究进展, 促进该领域的进一步发展。 |
| 英文摘要: |
| The applications of nuclear technology in industries, medicine, and other fields have increased the risk of radiation injury. Although some small-molecule drugs for radiation injury treatment have been applied clinically or are in preclinical research, their therapeutic efficacy is significantly limited by short circulation time and rapid metabolism. Nanomaterials have attracted growing attention with their outstanding bioactivity, chemical stability, tissue compatibility, and targeted delivery capabilities, therefore having the promise of offering the potential solutions to the limitations of current small-molecule drugs. However, their biosafety and clinical efficacy require further investigation. This review summarizes the design strategies and classifications of nanomaterials for radiation injury treatment, analyzes current research progress in their therapeutic applications, and introduces nanomaterial-based approaches for enhancing the elimination of internal radionuclide contamination. Finally, the challenges and future prospects of nanomaterials in radiation injury treatment are discussed. This review aims to provide researchers with a comprehensive understanding of recent advances in nanomaterial-based radiation injury therapeutics, thereby promoting further development in this field. |
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