| 王涤凡,蔡尚.线粒体在肠道辐射损伤病变中的作用及作为潜在防治靶点的研究进展[J].中华放射医学与防护杂志,2025,45(10):1025-1031.Wang Difan,Cai Shang.Role of mitochondria in pathological changes of radiation-induced intestinal injury and advances in research on mitochondria as potential targets for prevention and treatment[J].Chin J Radiol Med Prot,2025,45(10):1025-1031 |
| 线粒体在肠道辐射损伤病变中的作用及作为潜在防治靶点的研究进展 |
| Role of mitochondria in pathological changes of radiation-induced intestinal injury and advances in research on mitochondria as potential targets for prevention and treatment |
| 投稿时间：2024-12-23 |
| DOI：10.3760/cma.j.cn112271-20241223-00489 |
| 中文关键词: 肠道辐射损伤 线粒体 活性氧 程序性死亡 线粒体自噬 |
| 英文关键词:Radiation-induced intestinal injury Mitochondria Reactive oxygen species Apoptosis Mitochondrial autophagy |
| 基金项目:江苏省大学生创新创业训练计划项目(202310285167Y); 苏州医学院学生课外科研项目(2022YXYKWKY064) |
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| 中文摘要: |
| 肠道辐射损伤(RⅢ)是放射治疗常见的并发症之一, 目前缺乏安全、有效的治疗手段。为防治RⅢ, 研究人员致力于其机制的研究, 发现线粒体在RⅢ病理改变中发挥作用, 其中线粒体介导活性氧生成、调控细胞凋亡与线粒体自噬等是关键环节。本综述旨在阐述RⅢ中线粒体在肠道辐射损伤病理改变中的作用, 并介绍线粒体作为潜在防治靶点的研究进展。 |
| 英文摘要: |
| Radiation-induced intestinal injury (RⅢ) is identified as a common complication of radiotherapy. However, there exists a lack of safe and effective treatment method. To address this issue, researchers have made great efforts to explore the mechanisms underlying RⅢ, revealing that mitochondria contribute to the pathological changes of RⅢ, with the mitochondria-mediated generation of reactive oxygen species (ROS), the regulation of apoptosis, and mitochondrial autophagy representing key processes. This review aims to elucidate the role of mitochondria in pathological changes of RⅢ and to introduce the progress of research on mitochondria as potential targets for RⅢ prevention and treatment. |
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