| 贾笑笑,纪凯华,张曼曼,等.乳杆菌及其工程化益生菌在放射性肠损伤防治中的应用研究进展[J].中华放射医学与防护杂志,2025,45(10):1015-1024.Jia Xiaoxiao,Ji Kaihua,Zhang Manman,et al.Advances in research on the application of Lactobacillus and its engineered probiotics to the prevention and treatment of radiation-induced intestinal injury[J].Chin J Radiol Med Prot,2025,45(10):1015-1024 |
| 乳杆菌及其工程化益生菌在放射性肠损伤防治中的应用研究进展 |
| Advances in research on the application of Lactobacillus and its engineered probiotics to the prevention and treatment of radiation-induced intestinal injury |
| 投稿时间：2024-10-28 |
| DOI：10.3760/cma.j.cn112271-20241028-00412 |
| 中文关键词: 乳杆菌属 益生作用 辐射损伤 构建效率 |
| 英文关键词:Lactobacillus Probiotic function Radiation-induced injury Construction efficiency |
| 基金项目:国家自然科学基金(32071241, 82103837) |
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| 中文摘要: |
| 肠道是放射敏感器官, 放射性肠损伤是意外受照人员或盆腹腔恶性肿瘤放疗患者常见的辐射损伤之一。目前, 对于放射性肠损伤尚无有效防治措施。研发新的防治策略, 对于意外受照人员和肿瘤患者的预后和生活质量具有重要意义。乳杆菌属为革兰氏阳性菌, 广泛存在于人和动物体内。乳杆菌属具有维持肠道菌群稳态, 保护肠道屏障和调节免疫等作用, 具有明显益生功能。大量研究证明, 乳杆菌属对辐射损伤具有明显的防护和治疗作用, 能够显著改善辐射引起的肠道损伤。乳杆菌属的益生作用为其成为基因工程菌株的底盘菌提供了较高优先级, 然而影响乳杆菌属构建成基因工程菌株的因素较多, 限制了乳杆菌属作为底盘菌的应用。本文将综述乳杆菌属的益生作用, 重点介绍乳杆菌属及其工程化益生菌在辐射防护和治疗中的研究进展, 并且总结基于乳杆菌属底盘菌构建基因工程菌株的影响因素, 旨在为以乳杆菌属作为底盘菌开发具有辐射防护和治疗作用的基因工程菌株提供启示。 |
| 英文摘要: |
| Intestinal radiosensitivity makes radiation-induced intestinal injury (RⅢ) as a common complication among individuals exposed to accidental radiation and patients with abdominal or pelvic malignancies receiving radiotherapy. At present, there are no effective measures for the prevention and treatment of RⅢ. Developing novel prevention and treatment strategies is of great significance for improving the prognosis and quality of life for both individuals exposed to accidental radiation and cancer patients. Lactobacillus, a Gram-positive bacterium, is widely observed in humans and animals. It exhibits notable probiotic functions, including maintaining gut microbiota homeostasis, preserving intestinal barrier, and modulating immune responses. Substantial studies have demonstrated that Lactobacillus has remarkable protective and therapeutic effects against radiation-induced injury, specifically significantly alleviating RⅢ. These probiotic functions of Lactobacillus make it have high priority to become the chassis of genetically engineered strains. However, multiple factors influence the construction of a genetically engineered strain, limiting the application of Lactobacillus as a chassis. This review focuses on the probiotic functions of Lactobacillus, highlighting advances in research on Lactobacillus and its engineered probiotics in radiation protection and treatment. Furthermore, it summarizes key factors influencing the construction of genetically engineered strains based on the Lactobacillus chassis. It aims to provide insights for developing genetically engineered strains with radioprotective and therapeutic effects using Lactobacillus as the chassis. |
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