| 王晨阳,王烁,杨军,等.空间分割放射治疗研究进展[J].中华放射医学与防护杂志,2025,45(9):925-933.Wang Chenyang,Wang Shuo,Yang Jun,et al.Advances in research on spatially fractionated radiation therapy[J].Chin J Radiol Med Prot,2025,45(9):925-933 |
| 空间分割放射治疗研究进展 |
| Advances in research on spatially fractionated radiation therapy |
| 投稿时间：2025-04-09 |
| DOI：10.3760/cma.j.cn112271-20250409-00128 |
| 中文关键词: 空间分割放疗 放射生物学 临床应用 |
| 英文关键词:Spatially fractionated radiation therapy (SFRT) Radiobiology Clinical application |
| 基金项目:中央引导地方科技发展资金项目(科技创新基地项目246Z7707G) |
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| 中文摘要: |
| 常规放射治疗往往对肿瘤给与均匀剂量照射,而针对大体积肿瘤或者为避免周边器官的高剂量毒性反应,能够给与的有效剂量常常受到限制,影响治疗效果。空间分割放射治疗(SFRT)有望克服这一局限。SFRT在靶区内提供空间差异性照射,形成高剂量的峰区和低剂量谷区,这种不均匀分布的剂量区可能激活潜在的生物学效应杀伤肿瘤细胞、改善免疫微环境、激活免疫系统,同时在一定程度上降低了大体积肿瘤周围正常组织的受量。本文就SFRT技术的发展历程、放射生物学机制、相关参数、临床应用以及未来SFRT的发展趋势进行综述。 |
| 英文摘要: |
| Conventional radiotherapy tends to deliver uniform doses to tumors. However, to avoid high-dose-induced toxicity to surrounding organs or in the case of large-volume tumors, effective doses are frequently limited, thereby undermining the treatment efficacy. Spatially fractionated radiation therapy (SFRT) has the potential to overcome this limitation. Specifically, SFRT delivers spatially differential irradiation within target volumes, creating high-dose peak zones and low-dose trough zones. This uneven dose pattern may activate potential biological effects to kill tumor cells, improve the immune microenvironment, and activate the immune system. Besides, this pattern can reduce the dose to normal tissues surrounding large-volume tumors. This study provides a review of the development history, radiobiological mechanisms, relevant parameters, and clinical applications of SFRT, as well as its future trends. |
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