| 綦家成,卓维海,李俊豪,等.放射性核素内照射治疗剂量估算方法研究进展[J].中华放射医学与防护杂志,2025,45(8):810-817.Qi Jiacheng,Zhuo Weihai,Li Junhao,et al.Research progress on internal dose estimation mehtods for radionuclide therapy[J].Chin J Radiol Med Prot,2025,45(8):810-817 |
| 放射性核素内照射治疗剂量估算方法研究进展 |
| Research progress on internal dose estimation mehtods for radionuclide therapy |
| 投稿时间：2025-04-08 |
| DOI：10.3760/cma.j.cn112271-20250408-00127 |
| 中文关键词: 放射性核素治疗 体内成像 药代动力学模型 内照射剂量 剂量-效应 |
| 英文关键词:Radionuclide therapy In vivo imaging Pharmacokinetic model Internal radiation dose Dose-effect |
| 基金项目:国家自然科学基金面上项目(12375308);国家市场监督管理总局科技创新人才计划(QNBJ202304) |
|
| 摘要点击次数: 354 |
| 全文下载次数: 202 |
| 中文摘要: |
| 放射性核素内照射治疗的剂量估算对其疗效和安全性的正确评价及后续的临床研究十分必要。内照射治疗剂量估算通常要先掌握放射性核素在患者体内的分布及其动态变化情况,再计算蓄积在患者体内放射性核素发射的不同种类、不同能量电离辐射在肿瘤靶区和危及器官中的沉积能量。本文重点针对上述两个方面的研究方法进展和内照射剂量与生物效应关系的特点进行综述,对将来的部分研究方向做出展望,以期增进人们对内照射剂量估算的理解,为更加准确地开展放射性核素内照射治疗的临床评价提供理论与技术方法参考。 |
| 英文摘要: |
| Dose estimation of radiopharmaceutical therapy is essential for the accurate evaluation of its efficacy and safety, as well as for guiding subsequent clinical research. The dosimetry estimation process typically requires understanding of the in vivo spatial distribution and dynamic transportation of radionuclides, followed by calculation of the energy deposition in tumor target volume and organs at risk from ionizing radiation of varying types and energies released by accumulated radionuclides. This review focuses on advancements in the aforementioned research aspects and the relationship between internal radiation dose and biological effects. Furthermore, this review prospectively discusses future research directions, aiming to enhance comprehension of internal radiation dose estimation and provides theoretical frameworks and technical references for improving clinical evaluation accuracy in radiopharmaceutical therapy. |
| HTML 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |