| 李华玉,宋嘉盈,叶涛,等.乳腺癌PET/CT分子影像探针应用进展[J].中华放射医学与防护杂志,2025,45(5):497-502.Li Huayu,Song Jiaying,Ye Tao,et al.Advances in the application of PET/CT molecular imaging probes to the treatment of breast cancer[J].Chin J Radiol Med Prot,2025,45(5):497-502 |
| 乳腺癌PET/CT分子影像探针应用进展 |
| Advances in the application of PET/CT molecular imaging probes to the treatment of breast cancer |
| 投稿时间：2024-12-12 |
| DOI：10.3760/cma.j.cn112271-20241212-00474 |
| 中文关键词: 乳腺癌 放射性药物 正电子发射计算机体层成像(PET/CT) 分子影像 |
| 英文关键词:Breast cancer Radiopharmaceutical Positron emission tomography/computed tomography (PET/CT) Molecular imaging |
| 基金项目:浙江省自然科学基金(Y24H160037);宁波市自然科学基金(2023J021);宁波市科技计划项目(鄞科2016-87) |
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| 中文摘要: |
| 乳腺癌是严重危害女性健康的恶性肿瘤,近年来发病率不断升高,部分患者预后较差。超声、钼靶X射线摄影和MR是乳腺常用的影像学检查技术,但对乳腺癌的精准诊断及分期有一定局限性。正电子发射计算机体层成像(positron emission tomography/computed tomography, PET/CT)通过搭载靶向不同配体的放射性分子探针,在细胞和分子水平上对肿瘤进行成像,有助于病灶的精准定位和定性诊断,提高分期的准确性,从而减少患者活检次数,提高治疗效果。因此,临床实践中PET/CT逐步成为乳腺癌的重要影像检查方法,在病灶侵及范围评估、免疫分型预测、靶向治疗效果预估等方面发挥重要作用,具有广阔的应用前景。近年来该领域有较多的研究突破,本文就PET/CT不同分子探针在乳腺癌诊疗中的临床应用进展作一综述,旨在提高这方面的认识。 |
| 英文摘要: |
| Breast cancer, a malignant tumor that significantly endangers women's health, has shown a gradually rising incidence in recent years. Some breast cancer patients experienced poor prognosis. The commonly used imaging techniques for breast cancer include ultrasound, mammography, and magnetic resonance (MR), which suffer from certain limitations in accurately diagnosing and staging breast cancer. Positron emission tomography/computed tomography (PET/CT) enables tumor imaging at the cellular and molecular levels by utilizing radiolabeled molecular probes targeting different ligands. This technique facilitates precise localization and qualitative diagnosis of lesions to improve the staging accuracy, thereby reducing biopsy frequency and enhancing treatment effects for patients. Therefore, PET/CT has gradually developed into an essential imaging method for breast cancer in clinical practice. It plays a critical role in assessing the extent of lesion invasion, predicting immune subtypes, and estimating targeted therapy efficacy, holding promising application prospects. Recently, significant research breakthroughs have been achieved in this field. This review summarized the advances in clinical applications of different PET/CT molecular probes in the diagnosis and treatment of breast cancer, aiming to enhance the understanding of this aspect. |
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