中华放射医学与防护杂志

宋雪娇,李萌,石梅.头颈部肿瘤放化疗后感音神经性听力损失及防治的研究进展[J].中华放射医学与防护杂志,2025,45(4):368-373.Song Xuejiao,Li Meng,Shi Mei.Research advances in the prevention and treatment of sensorineural hearing loss following chemoradiotherapy for head and neck cancers[J].Chin J Radiol Med Prot,2025,45(4):368-373

头颈部肿瘤放化疗后感音神经性听力损失及防治的研究进展

Research advances in the prevention and treatment of sensorineural hearing loss following chemoradiotherapy for head and neck cancers

投稿时间：2024-10-01

DOI：10.3760/cma.j.cn112271-20241001-00390

中文关键词: 头颈癌放疗化疗感音神经性听力损失

英文关键词:Head and neck cancer (HNC) Radiotherapy Chemotherapy Sensorineural hearing loss (SNHL)

基金项目:国家自然科学基金项目(82272735)

作者	单位	E-mail
宋雪娇	空军军医大学第一附属医院放疗科, 西安 710032
李萌	空军军医大学药学系生物制药学教研室, 西安 710032
石梅	空军军医大学第一附属医院放疗科, 西安 710032	mshi82@fmmu.edu.cn

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中文摘要:

感音神经性听力损失(SNHL)是头颈部肿瘤(HNC)患者放射治疗或放化疗后耳毒性中最为严重的并发症。由于目前尚无有效的治疗药物,因此,SNHL严重影响着患者的生活质量。尽管放疗技术的进步在提高患者生存和保护危及器官上发挥了重要作用,但SNHL的发生仍不可避免。本文就SNHL的诊断、鉴别诊断、临床表现、评价标准、发生机制、风险因素和防治策略等内容进行概述,旨在为临床诊疗及预防提供研究思路。

英文摘要:

Sensorineural hearing loss (SNHL) is recognized as the most severe ototoxic complication following radiotherapy or chemoradiotherapy in patients with head and neck cancers (HNCs). It significantly impairs patients' quality of life due to the lack of effective drugs. Although advances in radiotherapy techniques have played a crucial role in improving patients' survival rates and protecting organs at risk, SNHL remains inevitable. This review presents the diagnosis, differential diagnosis, clinical manifestations, assessment criteria, pathogenesis, risk factors, and prophylactic/therapeutic strategies of SNHL, in order to provide novel insights for clinical diagnosis, treatment, and prevention.

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