| 杨思瑜,牛晓凤,邓丽娟,等.单细胞转录组测序在放射性损伤研究中的应用进展[J].中华放射医学与防护杂志,2025,45(3):249-254.Yang Siyu,Niu Xiaofeng,Deng Lijuan,et al.Advances in applications of single-cell RNA sequencing to research on radiation-induced injuries[J].Chin J Radiol Med Prot,2025,45(3):249-254 |
| 单细胞转录组测序在放射性损伤研究中的应用进展 |
| Advances in applications of single-cell RNA sequencing to research on radiation-induced injuries |
| 投稿时间：2024-05-07 |
| DOI：10.3760/cma.j.cn112271-20240507-00168 |
| 中文关键词: 单细胞转录组测序 放射性损伤 电离辐射 |
| 英文关键词:Single-cell RNA sequencing (scRNA-Seq) Radiation-induced injury Ionizing radiation |
| 基金项目:国家自然科学基金(82060313);云南省基础研究专项(202201AW070002);云南省科技人才与平台计划(202305AC160020) |
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| 中文摘要: |
| 放射治疗在治疗肿瘤的同时也会对周围正常组织造成不同程度的损伤。近年来,单细胞转录组测序(scRNA-seq)作为现代生物学领域的一种新兴技术,逐渐在放射性损伤研究领域中发挥着重要作用,研究人员从放射性脑损伤、心血管损伤、肺损伤、肠道损伤、皮肤损伤和造血系统损伤等多个领域进行深入研究,为揭示放射性损伤机制、评估损伤程度以及探索潜在的治疗方法提供新的视角。本文对单细胞转录组测序在放射性损伤研究中的应用进展进行综述。 |
| 英文摘要: |
| Radiotherapy can cause varying degrees of damage to surrounding normal tissues while treating tumors. In recent years, single-cell RNA sequencing (scRNA-Seq), an emerging technology in modern biology, has gradually played a significant role in research on radiation-induced injuries. Researchers have delved into a variety of radiation-induced brain injuries, including radiation-induced brain injury (RIBI), cardiovascular injury, lung injury, intestinal injury, skin injury, and hematopoietic injury. Their studies provide novel perspectives for revealing the mechanisms behind radiation-induced injuries, assessing the degree of injury, and exploring potential therapies. This study reviews the advances in the application of scRNA-seq to research on radiation-induced injuries. |
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