| 程旭,陈茉莉,赵国平,等.肠道微生物在放疗敏感性及辐射损伤中的研究进展[J].中华放射医学与防护杂志,2025,45(3):243-248.Cheng Xu,Chen Moli,Zhao Guoping,et al.Research advances in the role of gut microbiota in radiotherapy sensitivity and radiation-induced injury[J].Chin J Radiol Med Prot,2025,45(3):243-248 |
| 肠道微生物在放疗敏感性及辐射损伤中的研究进展 |
| Research advances in the role of gut microbiota in radiotherapy sensitivity and radiation-induced injury |
| 投稿时间：2024-04-21 |
| DOI：10.3760/cma.j.cn112271-20240421-00148 |
| 中文关键词: 肠道菌群 放射治疗 不良反应 免疫响应 |
| 英文关键词:Gut microbiome Radiotherapy Adverse effect Immune response |
| 基金项目:国家自然科学基金(32171240);中国科学院合肥肿瘤医院优秀医学青年人才计划(YQJH2023004) |
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| 中文摘要: |
| 放疗目前仍为多种肿瘤治疗的的重要手段之一,但其疗效和不良反应在个体间存在差异。近年来,肠道微生物与放疗反应之间的相互作用引起了广泛关注。肠道微生物通过影响免疫反应、肠道屏障功能和代谢过程,在放疗的耐受性和效果中发挥关键作用。调整肠道微生物组成,如使用益生菌、抗生素或饮食干预,可能有助于减轻放疗的不良反应,提高治疗效果。尽管面临机制研究和临床应用的挑战,现有研究为肿瘤治疗提供了新的视角。本综述强调肠道微生物在放疗中的重要作用,其不仅关系到治疗效果,更影响患者的耐受性与生活质量,并指出未来研究应深入探讨微生物调控与放疗效果优化之间的关系,以期将这些策略应用于临床,为患者提供更个性化的治疗方案。 |
| 英文摘要: |
| Radiotherapy remains one of the primary therapeutic modalities for various cancers. However, individual heterogeneity exists in treatment outcomes and adverse reactions. In recent years, the interaction between the gut microbiota and radiotherapy has garnered increasing attention. The gut microbiota plays a crucial role in modulating host immune responses, maintaining intestinal barrier integrity, and participating in metabolic processes, thereby influencing both the efficacy and tolerance of radiotherapy. Modulating gut microbiota composition through probiotics, antibiotics, or dietary interventions may reduce the toxic side effects induced by radiotherapy, thereby enhancing therapeutic outcomes. Despite numerous challenges in mechanistic studies and clinical application, current research has shed light on cancer therapies. This review emphasizes the significant role of gut microbiota in radiotherapy, impacting treatment outcomes and patients’ tolerance and quality of life. Future research should further explore the links between microbiota regulation and optimization of radiotherapy outcomes, with the prospect of translating these strategies into clinical practice to provide more personalized treatment options for patients. |
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