| 王清鑫,王中秋,王伟,等.铁死亡在放射损伤中的作用及机制研究进展[J].中华放射医学与防护杂志,2024,44(6):537-542.Wang Qingxin,Wang Zhongqiu,Wang Wei,et al.Advances in research on the role and mechanism of ferroptosis in radiation-induced injury[J].Chin J Radiol Med Prot,2024,44(6):537-542 |
| 铁死亡在放射损伤中的作用及机制研究进展 |
| Advances in research on the role and mechanism of ferroptosis in radiation-induced injury |
| 投稿时间：2023-08-14 |
| DOI：10.3760/cma.j.cn112271-20230814-00045 |
| 中文关键词: 放射治疗 放射损伤 铁死亡 |
| 英文关键词:Radiotherapy Radiation-induced injury Ferroptosis |
| 基金项目:国家自然科学基金(82272734);天津市医学重点学科(专科)建设项目(TJYXZDXK-009A) |
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| 中文摘要: |
| 放射治疗(放疗)是恶性肿瘤综合治疗的重要组成部分,肿瘤患者在接受放疗时正常组织会发生不同程度损伤,是放疗最常见的不良反应,也是影响放疗进程的一个重要因素。但目前对此尚无有效防治措施。铁死亡作为一种新型细胞死亡方式,多次被报道与放疗所致正常组织损伤存在密切联系。本文对铁死亡的调控机制及其与放射损伤之间关系的研究进展作一综述。 |
| 英文摘要: |
| Radiotherapy plays an important role in the comprehensive treatment of malignant tumors. Radiation-induced injury (RII) of normal tissue in tumor patients receiving radiotherapy, to varying degrees, is the most common adverse reaction of radiotherapy and an important factor influencing the course of radiotherapy. However, there is a lack of efficient prevention and treatment measures for RII. Ferroptosis, a novel type of cell death, has been reported several times to be closely associated with normal tissue damage induced by radiotherapy. This paper reviews the advances in research on ferroptosis, as well as its mechanism and association with RII. |
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