中华放射医学与防护杂志

薛珂,徐辉,岳保荣,等.我国女性乳腺体积密度及相关乳房特征定量研究[J].中华放射医学与防护杂志,2024,44(4):278-285.Xue Ke,Xu Hui,Yue Baorong,et al.A quantitative study of the volumetric breast density and related breast characteristics in Chinese women[J].Chin J Radiol Med Prot,2024,44(4):278-285

我国女性乳腺体积密度及相关乳房特征定量研究

A quantitative study of the volumetric breast density and related breast characteristics in Chinese women

投稿时间：2024-02-05

DOI：10.3760/cma.j.cn112271-20240205-00045

中文关键词: 乳房特征乳腺体积密度乳腺CBCT 乳腺X射线摄影

英文关键词:Breast Characteristics Volumetric breast density Breast cone-beam CT Mammography

基金项目:

作者	单位	E-mail
薛珂	中国疾病预防控制中心辐射防护与核安全医学所辐射防护与核应急中国疾病预防控制中心重点实验室世界卫生组织辐射与健康合作中心, 北京 100088
徐辉	中国疾病预防控制中心辐射防护与核安全医学所辐射防护与核应急中国疾病预防控制中心重点实验室世界卫生组织辐射与健康合作中心, 北京 100088	xuhui@nirp.chinacdc.cn
岳保荣	中国疾病预防控制中心辐射防护与核安全医学所辐射防护与核应急中国疾病预防控制中心重点实验室世界卫生组织辐射与健康合作中心, 北京 100088
丁艳秋	中国疾病预防控制中心辐射防护与核安全医学所辐射防护与核应急中国疾病预防控制中心重点实验室世界卫生组织辐射与健康合作中心, 北京 100088
牛振	天津市疾病预防控制中心职业病预防控制室, 天津 300011
杨云福	重庆市疾病预防控制中心, 重庆 400042
谭展	广东省职业病防治院, 广州 510300
叶兆祥	天津医科大学肿瘤医院放射科国家肿瘤临床医学研究中心天津市肿瘤防治重点实验室天津市恶性肿瘤临床医学研究中心乳腺癌防治教育部重点实验室, 天津 300060

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中文摘要:

目的本研究旨在利用乳腺锥形束CT(CBCT)的三维影像资料,定量分析我国部分地区女性乳腺体积密度和相关乳房特征,比较并分析地区间及年龄间的差异和分布规律。方法回顾性调查了位于我国华北、西南和华南的3家三级甲等医院的1 440位乳腺CBCT受检者的图像资料。利用科宁Imaging Viewer阅片系统中的测量工具和基于阈值分割的腺体分割显示工具,辅助测量各项乳房特征指标及乳腺体积密度(VBD)。乳房特征在不同地区之间,不同年龄组之间的差异采用Kruskal-Wallis H检验来评估;Spearman相关系数用于分析各项乳房特征与年龄之间,乳房尺寸和乳房密度特征之间的相关性。结果被调查女性胸壁有效直径(D_eff)和乳房厚度(CNL)、乳房体积(BV)和腺体体积(GV)及VBD的总体中位数分别为12.5和6.8 cm、374.5和48.6 cm³及14.6%。其中,不同地区女性的D_eff、CNL和BV显著不同,VBD在不同地区的分布差异无统计学意义(P>0.05)。CNL、BV与年龄呈显著正相关;GV和VBD与年龄呈显著负相关。VBD与D_eff、CNL和BV均存在显著负相关。结论本研究调查了我国多个地区女性的乳房尺寸及密度特征参数,可以为进一步开展非压迫乳房模型的建立、乳腺CBCT患者剂量评估、乳腺癌风险评估等相关研究提供数据基础。

英文摘要:

Objective To quantitatively analyse the volumetric breast density (VBD) and related breast characteristics of women in several regions of China and their distribution patterns in different regions and at different ages by using three-dimensional imaging data from breast cone-beam CT (CBCT). Method A total of 1 440 breast CBCT images from three tertiary hospitals in north, southwest and south China were retrospectively investigated. Measurements of VBD and breast characteristics were aided by a threshold-based segmentation tool and dedicated measurement tools in the Koning Imaging Viewer system. Differences in breast characteristics between regions and age groups were assessed using the Kruskal-Wallis H-test; Spearman correlation coefficients were used to analyze the correlation between each breast characteristic and age and between breast size and breast density characteristics. Results The median values for effective diameter of the breast at chest-wall (D_eff), chest-wall to nipple length (CNL), breast volume (BV), glandular volume (GV) and VBD for the surveyed groups were 12.5, 6.8 cm; 374.5, 48.6 cm³and 14.6%, respectively. The distributions of D_eff, CNL, BV and GV varies in different regions, and the distribution of VBD has no significant difference beetween regions. D_eff and CNL had a significant positive correlation with age. In comparison, GV and VBD had a significant negative correlation with age. D_eff, CNL and BV were all significantly negatively correlated with VBD. Conclusions This study investigated the parameters of breast size and density characteristics in women from several regions of China, which can provide the data basis for further studies on the establishment of non-compression breast phantom, dose assessment for breast CBCT patients, and breast cancer risk assessment.

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