| 李凤虎,梅烦,杜燕军,等.局部晚期宫颈癌同步放化疗中尿道受照剂量与泌尿系统并发症相关性研究[J].中华放射医学与防护杂志,2024,44(1):18-23.Li Fenghu,Mei Fan,Du Yanjun,et al.Correlations of irradiation dose to urethra with urinary complications in concurrent chemoradiotherapy for locally advanced cervical cancer[J].Chin J Radiol Med Prot,2024,44(1):18-23 |
| 局部晚期宫颈癌同步放化疗中尿道受照剂量与泌尿系统并发症相关性研究 |
| Correlations of irradiation dose to urethra with urinary complications in concurrent chemoradiotherapy for locally advanced cervical cancer |
| 投稿时间：2023-05-24 |
| DOI：10.3760/cma.j.cn112271-20230524-00159 |
| 中文关键词: 宫颈癌 盆腔放疗 不良反应 泌尿系统 |
| 英文关键词:Cervical cancer Pelvic radiotherapy Adverse reaction Urinary |
| 基金项目:贵州省抗癌协会科技计划项目(014[2023]) |
| 作者 | 单位 | E-mail | | 李凤虎 | 贵州医科大学附属医院肿瘤科, 贵阳 550004
贵州医科大学附属肿瘤医院妇科肿瘤科, 贵阳 550004 | | | 梅烦 | 贵州医科大学附属肿瘤医院妇科肿瘤科, 贵阳 550004 | | | 杜燕军 | 贵州医科大学附属医院肿瘤科, 贵阳 550004
贵州医科大学附属肿瘤医院妇科肿瘤科, 贵阳 550004 | | | 田雪 | 贵州医科大学附属医院肿瘤科, 贵阳 550004
贵州医科大学附属肿瘤医院妇科肿瘤科, 贵阳 550004 | | | 胡丽丽 | 贵州医科大学附属医院肿瘤科, 贵阳 550004
贵州医科大学附属肿瘤医院妇科肿瘤科, 贵阳 550004 | | | 洪卫 | 贵州医科大学附属医院肿瘤科, 贵阳 550004
贵州医科大学附属肿瘤医院妇科肿瘤科, 贵阳 550004 | | | 班红 | 贵州医科大学附属医院肿瘤科, 贵阳 550004
贵州医科大学附属肿瘤医院妇科肿瘤科, 贵阳 550004 | | | 殷水水 | 贵州医科大学附属肿瘤医院妇科肿瘤科, 贵阳 550004 | | | 胡银祥 | 贵州医科大学附属医院肿瘤科, 贵阳 550004
贵州医科大学附属肿瘤医院妇科肿瘤科, 贵阳 550004 | | | 卢冰 | 贵州医科大学附属医院肿瘤科, 贵阳 550004
贵州医科大学附属肿瘤医院妇科肿瘤科, 贵阳 550004 | | | 李杰慧 | 贵州医科大学附属医院肿瘤科, 贵阳 550004
贵州医科大学附属肿瘤医院妇科肿瘤科, 贵阳 550004 | 512111848@qq.com |
|
| 摘要点击次数: 2260 |
| 全文下载次数: 843 |
| 中文摘要: |
| 目的 探讨局部晚期宫颈癌患者盆腔外照射时泌尿系统不良反应与膀胱及尿道剂量的相关性。方法 回顾性收集贵州医科大学附属医院肿瘤科诊治的局部晚期宫颈癌患者行盆腔外照射计划中膀胱及尿道最大剂量点(Dmax)、最小剂量(Dmin)、平均剂量(Dmean)、计划靶区周围0.1、1、2 cm3接受的平均剂量(D0.1 cm3、D1 cm3、D2 cm3)及接受5、10、15、20、25、30、35、40、45、50 Gy受照体积占整个器官体积百分比(V5 Gy、V10 Gy、V15 Gy、V20 Gy、V25 Gy、V30 Gy、V35 Gy、V40 Gy、V45 Gy、V50 Gy)等相关剂量学参数及患者出现的尿频、尿急、尿痛等泌尿系症状。采用独立样本t检验及Logistic回归模型分析泌尿系症状与剂量学参数相关性。结果 膀胱及尿道的中位体积分别为294.8、4.71 cm3,以尿道各个参数的中位值为界分成两组,行单因素分析发现尿道Dmax、Dmin、Dmean、V5 Gy、V10 Gy、V15 Gy、V20 Gy、V25 Gy、V30 Gy、V35 Gy、V40 Gy、V45 Gy、V50 Gy与发生泌尿系并发症相关(t=14.30、21.65、32.19、33.36、16.62、17.91、21.52、20.11、12.27、37.25、30.18、36.24、21.98,P＜0.05),进一步行多因素分析显示,尿道D2 cm3、V20、V40及膀胱V40、D1 cm3、D2 cm3是预测泌尿系发生2级不良反应的独立因素(P＜0.05)。结论 建议限制尿道的D2 cm3、V20、V40以尽量减少2级泌尿系统并发症的风险。 |
| 英文摘要: |
| Objective To investigate the correlations of urinary adverse reactions with dose to the bladder and urethra during external pelvic irradiation for locally advanced cervical cancer. Methods This study retrospectively collected relevant dosimetric parameters and urinary symptoms, such as frequent, urgent, and painful urination, from locally advanced cervical cancer patients treated with external pelvic irradiation in the Department of Oncology, Affiliated Hospital of Guizhou Medical University. The dosimetric parameters examined in this study included the maximum, minimum, and mean doses to bladder and urethra (i.e., Dmax, Dmin and Dmean), mean doses received in an area of 0.1, 1, and 2 cm3 around the planning target volume, D0.1 cm3, D1 cm3, D2 cm3, and percentages of irradiated volumes in the whole organ volume under doses of 5, 10, 15, 20, 25, 30, 35, 40, 45, 50 Gy, V5 Gy, V10 Gy, V15 Gy, V20 Gy, V25 Gy, V30 Gy, V35 Gy, V40 Gy, V45 Gy, V50 Gy. Then the correlations between urinary symptoms and these dosimetric parameters were analyzed using the independent-sample t-test and the Logistic regression model. Results The median volumes of bladder and urethra were 294.8 and 4.71 cm3, respectively. Patients were divided into two groups based on the median division. The univariate analysis showed that urethral Dmax, Dmin, Dmean, V5 Gy, V10 Gy, V15Gy, V20 Gy, V25 Gy, V30 Gy, V35 Gy, V40 Gy, V45 Gy and V50 Gy correlated with urinary complications (t = 14.30, 21.65, 32.19, 33.36, 16.62, 17.91, 21.52, 20.11, 12.27, 37.25, 30.18, 36.24 and 21.98, P＜0.05). The multivariate analysis further indicates that urethral D2 cm3, V20 Gy, V40 Gy and Bladder V40 Gy, D1 cm3, D2 cm3 were independent predictors of grade 2 urinary adverse reactions (P＜0.05). Conclusions This study reported the correlations of relevant dosimetric parameters of urethra with urinary toxicity during external pelvic irradiation. It holds that urethral D2 cm3, V20 Gy and V40 Gy should be restricted to minimize the risks of grade 2 urinary complications. |
| HTML 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|