| 王菁,成超,贾雪丽,张福丽,李杰.基于倾向性评分匹配分析血小板淋巴细胞比值对食管癌患者预后的预测价值[J].中华放射医学与防护杂志,2023,43(12):974-978 |
| 基于倾向性评分匹配分析血小板淋巴细胞比值对食管癌患者预后的预测价值 |
| Exploring the prognostic value of platelet-lymphocyte ratios for esophageal cancer patients based on propensity score matching |
| 投稿时间：2023-10-07 |
| DOI：10.3760/cma.j.cn112271-20231007-00106 |
| 中文关键词: 食管肿瘤 血小板淋巴细胞比值 预后 |
| 英文关键词:Esophageal neoplasms Platelet-lymphocyte ratio Prognosis |
| 基金项目: |
|
| 摘要点击次数: 713 |
| 全文下载次数: 236 |
| 中文摘要: |
| 目的 采用倾向性评分匹配分析法探讨血小板淋巴细胞比值(PLR)对食管癌患者预后的预测价值。方法 回顾性分析2012年1月至2018年12月在山西省肿瘤医院收治的272例食管癌患者的临床资料。通过约登指数确定PLR最佳临界值。根据临界值将患者分为高PLR组和低PLR组,应用倾向性评分匹配(PSM)分析降低患者选择偏倚。采用单因素与多因素Cox回归分析患者的预后因素。生存分析采用Kaplan-Meier法和Log-Rank检验。结果 Cox单因素分析显示性别、吸烟史、TNM分期、体质量指数(BMI)、癌胚抗原(CEA)、系统免疫炎症指数(SII)、淋巴细胞/单核细胞比值(LMR)和PLR与食管癌患者预后相关(χ2=6.63、7.08、30.38、10.40、12.95、13.21、4.52、4.06、7.77,P<0.05)。PLR最佳临界值为159.93。倾向性评分匹配前高PLR组103例,低PLR组169例,SII和LMR有统计学意义(χ2=52.23、13.51,P<0.05)。倾向性评分匹配后,高PLR组62例,低PLR组62例,两组的预后相关指标之间差异无统计学意义(P>0.05),具有可比性。Cox多因素分析显示,倾向性评分匹配前后,TNM分期、BMI 、CEA和PLR均为食管癌患者预后的独立危险因素。高PLR组食管癌患者的生存期明显短于低PLR组(χ2=3.29,P<0.05)。结论 PLR对评估食管癌患者预后具有重要价值,PLR越高,生存期越短。针对PLR开展个体化干预,或许对改善患者预后有积极作用。 |
| 英文摘要: |
| Objective To explore the prognostic value of platelet-lymphocyte ratio (PLR) for esophageal cancer patients based on propensity score matching.Methods A retrospective analysis was conducted on the clinical data of 272 esophageal cancer patients in Shanxi Province Cancer Hospital from January 2012 to December 2018. The optimal cut-off value of PLR, which was determined using the Youden index, was used to classify patients into high- and low-PLR groups. Propensity score matching (PSM) was employed to reduce the selection bias of patients. The prognostic factors were analyzed through univariate and multivariate Cox regression. The Kaplan-Meier method and the Log-Rank test were adopted for survival analysis.Results Cox univariate analysis shows that prognosis of esophageal cancer patients was related to gender, smoking history, TNM stage, body mass index (BMI), carcinoembryonic antigen (CEA), systemic immune-inflammation index (SII), lymphocyte-monocyte ratio (LMR) and PLR (χ2=6.63, 7.08, 30.38, 10.40, 12.95, 13.21, 4.52, 4.06, 7.77, P < 0.05). The optimal cut-off value of PLR was 159.93. Before PSM, there existed statistically significant differences in SII and LMR between the high-PLR (n = 103) and low-PLR groups (n = 169) (χ2=52.23, 3.51, P<0.05). After PSM, there existed no statistical difference in prognostic indicators between the high-PLR (n=62) and low-PLR groups (n=62), suggesting that both groups were comparable. As revealed by Cox multivariate analysis, TNM stage, BMI, CEA, and PLR were independent risk factors for the prognosis of esophageal cancer patients both before and after PSM. The survival time of patients in the high-PLR group was significantly shorter than that in the low-PLR group (χ2=3.29, P < 0.05).Conclusions PLR hold critical value in evaluating the prognosis of esophageal cancer patients. A higher PLR is associated with a shorter survival time. Individualized intervention for PLR may play a positive role in improving the prognosis of patients. |
| HTML 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|