| 周婉仪,宫辉,邱睿,等.金刚石探测器在Flash照射实时剂量测量中的应用[J].中华放射医学与防护杂志,2023,43(9):729-735.Zhou Wanyi,Gong Hui,Qiu Rui,et al.Feasibility of diamond detector on Flash radiation dosimetry online[J].Chin J Radiol Med Prot,2023,43(9):729-735 |
| 金刚石探测器在Flash照射实时剂量测量中的应用 |
| Feasibility of diamond detector on Flash radiation dosimetry online |
| 投稿时间：2023-02-16 |
| DOI：10.3760/cma.j.cn112271-20230216-00036 |
| 中文关键词: 金刚石探测器 Flash照射 剂量测量 |
| 英文关键词:Diamond detector Flash radiation Dose measurement |
| 基金项目:国家重点研发计划项目（2021YFF0603600）；国家自然科学基金（12175114） |
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| 中文摘要: |
| 目的 通过实验探究人工金刚石探测器用于Flash照射剂量测量的可行性。方法 采用CIVIDECTM B1HV金刚石探头，设计了基于预积分方法的大动态范围电流测量电路，研制了一款实时输出脉冲电流的金刚石探测器样机，分别在电子束和X射线超高剂量率照射下测试其剂量和剂量率响应，并使用医用加速器对该金刚石探测器进行剂量标定。结果 电子束0.08~0.50 Gy/pulse范围内探测器输出积分电荷与参考脉冲剂量呈现较好的线性相关（R2=0.99），在电子束超高平均剂量率（400 Gy/s）和常规平均剂量率（0.3 Gy/s）照射模式下，剂量线性响应较好（R2=0.99），在X射线超高平均剂量率（75.5 Gy/s）和常规平均剂量率（0.5 Gy/s）照射模式下探测器输出积分电荷和参考剂量达到严格线性相关（R2=1），获得电荷（电流）-剂量（率）实用转换系数0.751 7 μC/Gy和0.753 5 μA·Gy·s-1。结论 该金刚石探测器在电子和X射线超高剂量率束流照射下均体现了较好的剂量线性响应，能够为Flash预临床实验提供较快速、准确的剂量监测，有潜力用于未来Flash放疗质量控制。 |
| 英文摘要: |
| Objective To explore the feasibility of synthetic diamond detector in use for Flash radiation dosimetry by designing a diamond dosimeter and conducting a series of dosimetric characteristic tests.Methods A diamond detector system prototype with real-time current output was developed using a CIVIDECTM B1HV diamond sensor and designing a large dynamic range current measurement circuit based on the pre-integration method. The dose (dose-rate) response linearity was tested under irradiation from both electron beam and X ray ultra-high dose rate. Dose (dose-rate) calibration was performed against a medical accelerator to gain the charge-dose transfer coefficient.Results Good linear correlation (R2=0.99) between detector output charge and reference dose per pulse was shown under electron beam irradiation of 0.08-0.50 Gy/pulse. Good linearity (R2=0.99) is also shown under irradiation from electron beam with ultra-high dose rate (400 Gy/s) and conventional dose rate (0.5 Gy/s). Strictly linear correlation (R2=1) was shown between detector output integrated charge and reference dose under X ray irradiation at ultra-high average dose rate (75.5 Gy/s) and conventional average dose rate (0.5 Gy/s). The charge-dose and current-dose rate conversion factors for practical use were 0.751 7 μC/Gy and 0.753 5 μA·Gy·s-1, respectively.Conclusions Considerable linearity of the diamond detector dose responses were shown under irradiation both from electron beam and X-ray beam, which could provide a relatively rapid and accurate dosimetry for Flash preclinical experiments. Furthermore, diamond detectors have great potential in the quality assurance for Flash radiotherapy. |
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