| 余威悦,洪兵,卢棚,梁立振,陈妮.基于微剂量学的钆中子俘获治疗释放低能电子相对生物效应计算[J].中华放射医学与防护杂志,2023,43(5):373-378 |
| 基于微剂量学的钆中子俘获治疗释放低能电子相对生物效应计算 |
| Computation of relative biological effectiveness of low-energy electrons release in gadolinium neutron capture therapy based on microdosimetry |
| 投稿时间：2022-08-22 |
| DOI：10.3760/cma.j.112271-20220822-00338 |
| 中文关键词: 钆中子俘获治疗 Geant4 微剂量学 相对生物效应 |
| 英文关键词:157GdNCT Geant4 Microdosimetry Relative Biological Effectiveness |
| 基金项目:安徽医科大学基础与临床合作研究提升计划项目(2019xkjT011);合肥综合性国家科学中心能源研究院重大培育项目(21KZS202,21KZS208);安徽高校协同创新项目(GXXT-2022-004) |
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| 中文摘要: |
| 目的 基于微剂量学方法计算钆中子俘获治疗(157GdNCT)中释放低能电子的相对生物效应(RBE)值。方法 使用蒙特卡罗(MC)程序Geant4-DNA包模拟钆中子俘获治疗中释放的低能电子在不同敏感靶标体积和物理模型中径迹结构的能量沉积分布情况及微剂量学参数,并基于微剂量动力学模型(MKM)获取其RBE值。结果 低能电子RBE值在不同的敏感靶标体积下差异性较大,且随着敏感靶标体积增大而减小。以敏感靶标直径6 nm的RBE值1.77为参考,敏感靶标直径10 nm的RBE值1.53,相比于6 nm的差异百分比为13%,而直径15 nm的RBE值1.40,相比于6 nm的差异百分比高达21%。不同Geant4-DNA物理模型对低能电子RBE影响较小。以物理模型option2的RBE值1.53作为参考,option6和option7的RBE值分别为1.49和1.52,相比于option2的差异百分比分别为2.6%和0.6%。结论 利用MKM计算157GdNCT释放低能电子在不同敏感靶标体积及物理模型下的RBE值为1.40~1.77。 |
| 英文摘要: |
| Objective To calculate the relative biological effectiveness (RBE) value of the released low-energy electrons in gadolinium neutron capture therapy (157GdNCT) based on microdosimetry. Methods The Monte Carlo (MC) code Geant4-DNA package was used to simulate the energy deposition distribution and microdosimetry parameters of low-energy electrons released during gadolinium neutron capture treatment in different sensitive target volumes and physical models on track structures. On this basis, RBE value was obtained based on the microdosimetry kinetic model (MKM). Results The low-energy electron RBE value was highly variable in different sensitive target volumes and decreases with increasing sensitive target volumes. With 6-nm-diameter sensitive target as reference, RBE value was 1.77 for 6-nm diameter, 1.53 for 10 nm diameter with percentage difference 13%, and 1.40 for 15-nm diameter with percentage difference of 21%, respectively. The effect of different Geant4-DNA physical models on the RBE of low-energy electrons was small. Using the RBE value of 1.53 for physical model option2 as reference, the RBE values of option6 and option7 were 1.49 and 1.52, respectively, with the percentage differences of 2.6% and 0.6%, respectively. Conclusions The RBE values of low energy electrons released by 157GdNCT in different sensitive target volumes and physical models were calculated by MKM to be 1.40-1.77. |
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