| 邓林,王少清,冷兴丽,尧鹏,李萃萃.放射性肾病研究进展[J].中华放射医学与防护杂志,2023,43(4):314-320 |
| 放射性肾病研究进展 |
| Research progress of radiation nephropathy |
| 投稿时间：2022-12-07 |
| DOI：10.3760/cma.j.cn112271-20221207-00474 |
| 中文关键词: 放射性肾病 发病机制 肿瘤治疗 |
| 英文关键词:Radiation nephropathy Pathogenesis Cancer treatment |
| 基金项目:中核医疗2021年度核医科技创新重点项目(ZHYLZD2021005);四川省中医药管理局中医药科研课题项目(2021MS517);北京医卫健康公益基金会医学科研项目(YWJKJJHKYJJ-KH19007) |
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| 中文摘要: |
| 放射治疗是恶性肿瘤治疗的重要组成部分,但同时也是造成局部正常组织损伤的原因之一,如在盆腹腔肿瘤放射治疗过程中常引起放射性肾病。放射性肾病确切的发病机制仍不清楚,目前认为主要与氧化应激、细胞衰老以及基因层面的改变等因素有关,目前尚无有效的治疗措施。随着肿瘤患者生存期的延长,放射性肾病越来越受到重视。本文主要从发病机制、治疗等方面综述放射性肾病的研究进展,旨在为放射性肾病的研究和临床诊治提供参考。 |
| 英文摘要: |
| Radiotherapy is an important treatment for malignant tumors. However, it is also one cause of damage to local normal tissues, such as radiation nephropathy, which is frequently induced during the radiotherapy of abdominal and pelvic tumors. The exact pathogenesis of radiation nephropathy is still unclear and is believed to be related mainly to factors including oxidative stress, cell aging, and gene changes presently. Moreover, there is a lack of effective treatments for radiation nephropathy. With an increase in the survival of tumor patients, radiation nephropathy has received increasing attention. This article mainly reviewed the research progress of radiation nephropathy from the aspects of pathogenesis and treatments, aiming to provide a reference for the research and clinical diagnosis and treatment of radiation nephropathy. |
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