| 敖兴坤,严紫艳,顾永清.上皮间质转化在放射性肺纤维化中的作用及治疗策略[J].中华放射医学与防护杂志,2023,43(4):307-313.Ao Xingkun,Yan Ziyan,Gu Yongqing.The role and treatment strategy of epithelial-mesenchymal transition in radiation-induced pulmonary fibrosis[J].Chin J Radiol Med Prot,2023,43(4):307-313 |
| 上皮间质转化在放射性肺纤维化中的作用及治疗策略 |
| The role and treatment strategy of epithelial-mesenchymal transition in radiation-induced pulmonary fibrosis |
| 投稿时间：2022-11-11 |
| DOI：10.3760/cma.j.cn112271-20221111-00443 |
| 中文关键词: 放射性肺纤维化 上皮间质转化 信号转导 表观遗传 药物治疗 |
| 英文关键词:Radiation-induced pulmonary fibrosis Epithelial-mesenchymal transition Signal transduction Epigenetics Drug therapy |
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| 中文摘要: |
| 放射性肺纤维化(radiation-induced pulmonary fibrosis,RIPF)是核辐射事故、骨髓移植预处理及胸部肿瘤放疗后最严重的晚期并发症之一,其形成过程十分复杂,发病机制也尚未完全阐明。近年来研究发现,电离辐射诱导肺上皮细胞发生上皮间质转化(epithelial-mesenchymal transition,EMT)是RIPF发生发展的关键环节。本文对电离辐射诱导肺EMT在RIPF发生发展中的作用及以EMT为潜在治疗靶点的相关药物做一综述,为今后研发RIPF的治疗药物提供思路。 |
| 英文摘要: |
| Radiation-induced pulmonary fibrosis (RIPF) is one of the most serious late complications after nuclear radiation accident, bone marrow transplantation pretreatment and thoracic tumor radiotherapy. The formation process of RIPF is complicated and the pathogenesis has not been fully elucidated. Recent studies have shown that radiation-induced epithelial-mesenchymal transition (EMT) of lung epithelial cells is an indispensable segment of RIPF. This article reviews the role of radiation-induced lung EMT in the occurrence and development of RIPF and related drugs with EMT as a potential therapeutic target, providing ideas for the development of therapeutic drugs for RIPF in the future. |
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