| 周盛祥,唐艳,唐鹏,等.血铀浓度与肾损伤的关联性研究[J].中华放射医学与防护杂志,2023,43(4):276-283.Zhou Shengxiang,Tang Yan,Tang Peng,et al.Correlation analysis between uranium exposure and renal injury[J].Chin J Radiol Med Prot,2023,43(4):276-283 |
| 血铀浓度与肾损伤的关联性研究 |
| Correlation analysis between uranium exposure and renal injury |
| 投稿时间：2022-11-29 |
| DOI：10.3760/cma.j.cn112271-20221129-00462 |
| 中文关键词: 血铀浓度 肾损伤 病例-对照 条件logistic回归 |
| 英文关键词:Plasma uranium Renal injury Case-control Conditional logistic regression |
| 基金项目:湖南省重点研发项目(2022SK2089);湖湘青年人才计划项目(2021RC3107) |
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| 中文摘要: |
| 目的 研究人群血铀浓度与肾损伤间的关联。方法 在湖南省4个铀矿分布地区开展病例对照研究,分别纳入102例肾损伤病例和102例对照为病例组和对照组。使用条件logistic回归模型分析血铀浓度与肾损伤间的关联,用限制性立方样条回归分析二者间的剂量反应关系。采用线性回归模型及Spearman相关来分析血铀浓度与肾损伤指标间的关联。结果 全体研究对象血铀的中位浓度为8.94 ng/L,病例组为10.19 ng/L。分析结果表明,血铀可能是肾损伤的危险因素,二者间存在剂量反应关系,且呈非线性关联(χ2=5.15,P<0.05)。血铀浓度高暴露组发生肾损伤的危险性是低暴露组的4.21倍。血铀浓度与肾小球滤过率、血肌酐及β2微球蛋白等肾损伤指标关联密切(r=0.211、-0.142、0.195,P<0.05)。结论 本研究表明血铀浓度与人群肾损伤之间存在统计学关联,该结果可为肾损伤的预防提供流行病学依据。 |
| 英文摘要: |
| Objective To analyze the relationship between plasma uranium concentration and renal injury.Methods A case-control study was conducted in Hunan province, involving 102 renal injury cases and 102 matched controls. The association between plasma uranium concentration and renal injury was analyzed using conditional logistic regression models, and the dose-response relationship was analyzed through restricted cubic spline regression. The linear regression model and Spearman correlation were used to analyze the association between plasma uranium concentration and renal injury indicators.Results The median of plasma uranium concentration was 8.94 ng/L in all subjects and 10.19 ng/L in the case group. The plasma uranium may be a risk factor for renal injury, with a dose-response relationship between the both representing nonlinear association (χ2=5.15, P<0.05). The risk of renal injury was 4.21 times higher in the group exposed to highest uranium concentration than that in the group exposed to lowest uranium concentration. Plasma uranium concentration was closely related to glomerular filtration rate, serum creatinine and β2-microglobulin (r=0.211, -0.142, 0.195, P<0.05).Conclusions The plasma uranium concentration is significantly associated with the renal injury, which may provide epidemiology evidence for the prevention of renal injury. |
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