| 张俊,张永胜,曹志飞.细胞焦亡信号通路在放射损伤中的研究进展[J].中华放射医学与防护杂志,2022,42(10):817-822 |
| 细胞焦亡信号通路在放射损伤中的研究进展 |
| Research progress on the mechanism of cell pyroptosis signaling pathways in radiation injury |
| 投稿时间：2022-05-27 |
| DOI：10.3760/cma.j.cn112271-20220527-00226 |
| 中文关键词: 细胞焦亡 放射治疗 放射损伤 电离辐射 gasdermin家族 |
| 英文关键词:Pyroptosis Radiotherapy Radiation injury Ionizing radiation Gasdermin family |
| 基金项目:江苏省卫生健康委医学科研项目(H2019071);苏州大学附属第二医院核技术医学应用重点人才项目(XKTJ-HRC2021002) |
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| 中文摘要: |
| 细胞焦亡是一种炎症性的程序性细胞死亡;与凋亡不同,细胞焦亡时总伴随着炎症反应。研究发现,细胞焦亡与多种疾病的发生、发展密切相关。在放射治疗引起的放射损伤中,细胞焦亡也发挥着重要作用。电离辐射使得细胞内的DNA断裂,产生氧自由基,而两者正是细胞焦亡良好的诱导剂。因此,本文从细胞焦亡的信号通路入手,综述了细胞焦亡在放射损伤中的研究进展,以期为减弱或阻断放射损伤提供新的思路。 |
| 英文摘要: |
| Pyroptosis is an inflammatory programmed cell death. Unlike apoptosis, pyroptosis is always accompanied by inflammation. It has been found that cell pyroptosis is closely related to the occurrence and development of many diseases. Pyroptosis also plays an important role in radiation injury caused by radiotherapy. Ionizing radiation breaks DNA in cells and induces oxygen free radicals, which are good inducers of pyroptosis. Therefore, this paper reviewed the research progress on the mechanism of cell pyroptosis in radiation injury from the perspective of relative signaling pathways, in order to provide new ideas for weakening or blocking radiation injury. |
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