中华放射医学与防护杂志

王佳豪,邱睿,胡安康,康天良,冯泽臣,牛延涛,李君利.女性乳腺体积密度及分布的影像学初步研究[J].中华放射医学与防护杂志,2022,42(10):806-811

女性乳腺体积密度及分布的影像学初步研究

Preliminary imaging study on the distribution of female Volumetric Breast Density

投稿时间：2022-05-27

DOI：10.3760/cma.j.cn112271-20220527-00229

英文关键词:Mammography Volumetric breast density Glandularity

基金项目:国家自然科学基金(11875036)

作者	单位	E-mail
王佳豪	清华大学工程物理系粒子技术与辐射成像教育部重点实验室, 北京 100084
邱睿	清华大学工程物理系粒子技术与辐射成像教育部重点实验室, 北京 100084	qiurui@tsinghua.edu.cn
胡安康	清华大学工程物理系粒子技术与辐射成像教育部重点实验室, 北京 100084
康天良	首都医科大学附属北京同仁医院放射科, 北京 100730
冯泽臣	北京市疾病预防控制中心放射卫生防护所, 北京 100013
牛延涛	首都医科大学附属北京同仁医院放射科, 北京 100730
李君利	清华大学工程物理系粒子技术与辐射成像教育部重点实验室, 北京 100084

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中文摘要:

目的利用乳腺X射线摄影检查资料,描述和评估受检者女性不同年龄段乳腺体积密度(VBD)的分布规律。方法基于北京市某三甲医院2010年1月—2016年12月期间1 140人次乳腺X射线摄影图像,使用Volpara 1.5.1评估女性的VBD。根据美国乳腺影像报告和数据系统对VBD进行分级,将样本群体年龄根据中位数分成两组,两组间均数比较采用两独立样本t检验。为进一步分析年龄因素的影响,将年龄细化分为4组(< 40 岁、40~49 岁、50~59 岁、≥60 岁),多组间均数比较采用单因素方差分析评估,分别评估不同年龄组受检者的乳房压迫厚度(CBT)、乳房体积(BV)、腺体体积(GV)和VBD。结果年龄中位数为50岁,50岁及以上受检者的CBT和BV明显>50以下受检者(t=-8.99、-7.92,P<0.001),而GV和VBD明显<50以下受检者(t=8.11、18.49,P<0.001)。CBT、BV、GV和 VBD各指标在4个年龄组间的差异具有统计学意义(F=27.10、22.34、25.70、122.03,P<0.001)。年龄在60岁及以上的受检者的VBD最低(t=-12.56、-15.27、-4.57,P<0.001),VBD与年龄呈负相关(r=0.47,P<0.001)。结论受检者CBT和BV与年龄呈正相关,GV和VBD与年龄呈负相关。

英文摘要:

Objective To describe the distribution of volumetric breast density(VBD) in different ages of Chinese women based on X-ray mammograms.Methods Based on mammographic images of 1 140 patients from January 2010 to December 2016 in a hospital in Beijing, the VBD of women was assessed by Volpara 1.5.1 and graded according to breast imaging reporting and data system published by American College of Radiology. The patients were divided into two groups according to the median age, and the two independent samples t-test was used to compare them. The patients were also divided into four groups according to age ( <40 years, 40-49 years, 50-59 years, ≥ 60 years), and the breast thickness, breast volume, glandular volume, and VBD were compared using a One-way ANOVA analysis.Results The median age was 50 years. The compressed breast thickness and breast volume in patients over 50 years were significantly higher than those in patients below 50 years (t= -8.99, -7.92, P<0.001), while glandular volume and VBD were significantly lower than those below 50 years (t= 8.11, 18.49, P<0.001). The compressed breast thickness, breast volume, glandular volume, and VBD were statistically significant different among four groups (F=27.10, 22.34, 25.70, 122.03, P<0.001). Patients over 60 years had the lowest VBD (t=-12.56, -15.27, -4.57, P<0.001). VBD was negatively correlated with ages (r=0.47, P<0.001).Conclusions The compressed breast thickness and breast volume increased with ages, while the glandular volume and VBD decreased with ages.

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