| 董帅,梁海生,畅磊,等.STAT3在电离辐射响应、肿瘤发展以及组织修复中的作用[J].中华放射医学与防护杂志,2022,42(9):722-726.Dong Shuai,Liang Haisheng,Chang Lei,et al.Roles of STAT3 in radiation response, tumor progression and tissue repair[J].Chin J Radiol Med Prot,2022,42(9):722-726 |
| STAT3在电离辐射响应、肿瘤发展以及组织修复中的作用 |
| Roles of STAT3 in radiation response, tumor progression and tissue repair |
| 投稿时间：2022-06-08 |
| DOI：10.3760/cma.j.cn112271-20220608-00246 |
| 中文关键词: STAT3 电离辐射 肿瘤发展 肿瘤微环境 组织修复 |
| 英文关键词:STAT3 Ionizing radiation Tumor progression Tumor microenvironment Tissue reparation |
| 基金项目:国家自然科学基金(31971165,82192883,82173465);霍英东基金会青年基金(171017);江苏省科技计划-面上项目(KB20191422);苏州市姑苏创新创业领军人才计划(ZXL2022454) |
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| 中文摘要: |
| 信号转导和转录激活因子 (STAT)是一个细胞质转录因子家族,共有7种蛋白,包括STAT-1、-2、-3、-4、-5A、-5B和-6,编码STAT家族的基因位于2号(STAT1和STAT4)、12号(STAT2和STAT6)和17号(STAT3、5A和5B)染色体上。在这7种蛋白中,STAT3和STAT5与肿瘤进展之间的关联性最强,且电离辐射可以对STAT3水平产生影响。STAT3的持续活化能够调节多种功能,包括细胞增殖、细胞周期进程、细胞凋亡、血管生成和免疫逃逸。STAT3在其生物学功能及其激活剂作用方面高度复杂,因此,进一步研究STAT3生物学功能及其信号通路具有十分重要的意义。 |
| 英文摘要: |
| Signal transducer and activator of transcription (STAT) is a family of cytoplasmic transcription factors including seven proteins of STAT-1,-2,-3,-4,-5A,-5B and-6.The genes encoding the STAT family are located on are located on chromosome 2(STAT1 and STAT4),chromosome 12(STAT2 and STAT6) and chromosome 17(STAT3,STAT5A and STAT5B).Among these seven proteins,STAT3 and STAT5 have the strongest correlation with tumor progression,and ionizing radiation can affect STAT3 level.Continuous activation of STAT3 can regulate a variety of functions,including cell proliferation,cell cycle progression,apoptosis,angiogenesis and immune escape.STAT3 is highly complex in its biological function and activator action.Therefore,it is of great significance to further study the biological function and signaling pathway of STAT3. |
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