| 孔海云,贺晓东.国产首台质子治疗装置治疗计划系统建模与验证调试方法初探[J].中华放射医学与防护杂志,2022,42(8):605-610 |
| 国产首台质子治疗装置治疗计划系统建模与验证调试方法初探 |
| A preliminary study on modeling and commissioning method of the treatment planning system used in the first domestic proton therapy device |
| 投稿时间：2021-09-08 |
| DOI：10.3760/cma.j.cn112271-20210908-00370 |
| 中文关键词: 质子治疗 治疗计划系统 建模 剂量验证 |
| 英文关键词:Proton therapy Treatment planning system (TPS) Modeling Dose verification |
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| 中文摘要: |
| 目的 介绍国产首台质子治疗装置配套治疗计划系统（未取得注册证的Raystation10B科研版）建模与初步剂量验证的方法与结果。并通过剂量验证结果分析验证建模精度。方法 治疗计划系统（TPS）建模方法主要包括积分深度剂量（integrated depth dose，IDD）曲线的采集与建模、空气中束斑采集与建模、通过扫描点距为2.5 mm、照射野为10 cm×10 cm的方野来进行绝对剂量标定建模。本研究通过测量3种不同复杂程度案例的剂量分布并与TPS的剂量分布对比，验证和分析建模精度并给出机器束流参数的要求和调试建议。结果 TPS模型拟合的低能区IDD曲线峰值比实际测量值偏低，中高能区拟合的较好。所有能区射程都拟合准确。3种不同复杂程度案例实际测量与治疗计划靶区平均剂量偏差都在±5%（国家型式检测标准）以内，高剂量梯度区域位置偏差（DTA）都<3 mm。结论 该治疗计划系统的建模精度总体上满足测量验证的要求。但由于TPS模型中蒙特卡罗模拟的IDD分辨率低且低能区布拉格峰非常尖锐，低能区IDD建模拟合精度不足。 |
| 英文摘要: |
| Objective To introduce the method and result of the modeling and preliminary dose verification of the treatment planning system used in the first domestic proton therapy device of China (Raystation 10B, a system of scientific research version with no available registration certificate) and to verify the modeling accuracy using dose verification result. Methods The modeling method for a treatment planning system (TPS) mainly included the data acquisition and modeling of integrated depth dose (IDD) curves, the data acquisition and modeling of beam spot profiles in air, and the calibration and modeling of absolute dose by scanning a 10 cm×10 cm square field with a spot spacing of 2.5 mm. By measuring the dose distributions in three cases with different complexity levels and comparing them with the dose distributions calculated using the TPS, this study verified and analyzed the modeling accuracy and proposed the requirements for beam parameters and the commissioning suggestions of the proton device.Results The peak values of the IDD curves of low-energy regions fitted using the TPS model were less than the measured values, while those of medium- and high-energy regions fitted using the TPS model approximated the measured values. The range in all energy regions fitted accurately. For the three cases with different complexity levels, the deviation between the average dose calculated by the TPS and that measured was within ±5% (national standard for type tests of medical devices). Moreover, the DTA of high-dose-gradient areas was less than 3 mm.Conclusions The modeling accuracy of the TPS generally meets the verification requirements. However, due to the low resolution of IDDs obtained by Monte Carlo simulation in the TPS model and the sharp Bragg peaks of low-energy regions, the IDD modeling accuracy of low-energy regions is insufficient. |
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